1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. sulfo-SPDB-DM4

sulfo-SPDB-DM4 

目录号: HY-101141
产品使用指南

sulfo-SPDB-DM4 是 ADC 的一部分,由 maytansinebased payload (DM4,一种微管抑制剂) 与 sulfo-SPDB 连接而成。

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sulfo-SPDB-DM4 Chemical Structure

sulfo-SPDB-DM4 Chemical Structure

CAS No. : 1626359-59-8

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  • 生物活性

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  • 参考文献

生物活性

sulfo-SPDB-DM4 is a drug-linker conjugate for ADC by using the maytansinebased payload (DM4, an antitubulin agent) via the sulfo-SPDB linker.

IC50 & Target

Maytansinoids

 

体外研究
(In Vitro)

DM4, a structural analogue of maytansine, is a new thiol-containing and potent maytansinoid. DM4 is a cytotoxic maytansinoid drug. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Maytansinoids inhibit tubulin polymerization and microtubule assembly and enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1075.66

Formula

C46H63ClN4O17S3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
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质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
sulfo-SPDB-DM4
目录号:
HY-101141
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