2. GPCR/G Protein Neuronal Signaling
  3. GLP Receptor GCGR Neuropeptide Y Receptor
  4. TC4

TC4 是一种高度平衡型的单分子四重激动剂，可分别激活 GIPR、GLP-1R、GcgR 和 Y2R，其 IC50 分别为 0.95、31、81 和 1100 nM。TC4 在 GLP-1R 上表现出极强的信号偏倚，β-抑制蛋白 2 (βArr2) 招募效能极低，这种强烈的 cAMP 偏好性被认为能最大化代谢益处 (如减重、降糖) 同时可能最小化由 β-抑制蛋白募集介导的副作用 (如受体脱敏)。TC4 可用于研究肥胖和糖尿病。

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Custom Peptide Synthesis

TC4

TC4 Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

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规格 是否有货
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Customer Review

TC4 相关抗体

Top Publications Citing Use of Products

查看 Neuropeptide Y Receptor 亚型特异性产品:

查看所有亚型
NPY Y1 receptor NPY Y2 receptor NPY Y4 receptor NPY Y5 receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TC4 is a highly balanced single-molecule quadruple agonist that can respectively activate GIPR, GLP-1R, GcgR, and Y2R with IC50 values of 0.95, 31, 81, and 1100 nM respectively. TC4 exhibits extremely strong signal bias on GLP-1R and has very low recruitment efficacy for β-inhibitor protein 2 (βArr2) and this strong cAMP preference is believed to maximize metabolic benefits (such as weight loss and hypoglycemia) while possibly minimizing side effects mediated by β-inhibitor protein recruitment (such as receptor desensitization). TC4 can be used for research on obesity and diabetes[1].
分子量

6069.87

Formula

C282H433N69O80
Sequence

Tyr-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-Leu-Leu-Asp-Arg-{Lys(AEEA-gGlu-C20 diacid)}-Ala-Gln-Ala-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Leu-Arg-His-Tyr-Val-Asn-Trp-Leu-Thr-Arg-Gln-Arg-Tyr-NH2
Sequence Shortening

Y-{Aib}-QGTFTSDYSILLDR-{Lys(AEEA-gGlu-C20 diacid)}-AQAAFIEYLLEGGPSLRHYVNWLTRQRY-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TC4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TC4TC 4TC-4GLP ReceptorGCGRNeuropeptide Y ReceptorGlucagon ReceptorNPY receptorUnimolecular tetra-agonistG protein-coupled receptor (GPCR)Biased signaling (cAMP/β-arrestin)Metabolic homeostasisPeptide engineeringLipidation (protraction)Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-P11275
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