2. Apoptosis
  3. Apoptosis
  4. Telomerase-IN-4

Telomerase-IN-4 是一种有效的端粒酶 (telomerase) 抑制剂。Telomerase-IN-4 具有抗增殖活性，诱导细胞凋亡 (apoptosis)。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Telomerase-IN-4

Telomerase-IN-4 Chemical Structure

CAS No. : 2892295-10-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Telomerase-IN-4 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Telomerase-IN-4 is a potent telomerase inhibitor. Telomerase-IN-4 has antiproliferative activity and induces apoptosis[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
17.09 μg/mL
Compound: 8e
Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 36525642]
MCF7 IC50
9.47 μg/mL
Compound: 8e
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 36525642]
体外研究
(In Vitro)

Telomerase-IN-4 (compound 8e; 0.1-100 μg/mL; 72 h) 对两种癌细胞系都有抗肿瘤作用，对 MCF-7 和 A549 细胞的 IC50 值分别为 9.47 和 17.09 μg/mL[1]。
Telomerase-IN-4 (9.467 μg/mL; 48 h) 将细胞周期阻滞在 S 期，诱导 MCF-7 细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Telomerase-IN-4 相关抗体:

Cell Viability Assay[1]

Cell Line: MCF-7 and A549 cells
Concentration: 0.1, 1, 10, and 100 μg/mL
Incubation Time: 72 h
Result: Inhibited cell growth in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: MCF-7 cells
Concentration: 9.467 μg/mL
Incubation Time: 48 h
Result: Had an apoptosis percentage of 42.51%.

Cell Cycle Analysis[1]

Cell Line: MCF-7 cells
Concentration: 9.467 μg/mL
Incubation Time: 48 h
Result: Arrested cell cycle at the S phase of cell growth by more than 1.46 folds compared to that of the control.

Western Blot Analysis[1]

Cell Line: MCF-7 cells
Concentration: 9.467 μg/mL
Incubation Time: 48 h
Result: Decreased in ALT and AST levels by 36.12 and 29.77%, respectively.
体内研究
(In Vivo)

Telomerase-IN-4 (5 mg/kg; i.p.; 每周三次，共两周; 瑞士白化雌性小鼠) 具有抗癌活性，抑制肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss albino female mice (25-30 g)[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injectionthree; times per week for two weeks
Result: Reduced both the weight and volume of the tumor by 74.34 and 62.12%, respectively.
分子量

406.52

Formula

C21H18N4OS2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Telomerase-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Telomerase-IN-42892295-10-0ApoptosisantiproliferativetumorMCF-7A549S phaseInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Telomerase-IN-4
目录号：
HY-152076
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z