2. Neuronal Signaling
  3. Tau Protein
  4. Tilavonemab

Tilavonemab  (Synonyms: 替拉奈单抗; ABBV-8E12; C2N-8E12)

目录号: HY-P99163 纯度: 99.59%
COA 技术支持

Tilavonemab (ABBV-8E12) 是一种人源化抗 tau 的单克隆抗体，可与 tau 蛋白 N 端附近的 25-30 氨基酸结合。Tilavonemab 能阻断人和小鼠神经元摄取 tau 聚集体的能力。Tilavonemab 可用于阿尔兹海默症和其他 tau 疾病的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CAS No. : 2096513-89-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥1200
In-stock
5 mg ￥3600
In-stock
10 mg ￥6100
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Tilavonemab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tilavonemab (ABBV-8E12) is a humanized anti-tau monoclonal antibody that binds to amino acids 25-30 near the N-terminus of the tau protein. Tilavonemab can block the ability of human and mouse neurons to uptake tau aggregates. Tilavonemab can be used for research on Alzheimer’s disease and other tauopathies[1][2][3].

同型

Human IgG4 kappa
推荐同型对照抗体
反应种属

Human
IC50 & Target

Tau
体内研究
(In Vivo)

Tilavonemab 在人-tau 转基因小鼠模型中，将其递送到脑脊液或腹膜中可降低不溶性 tau 的水平，并减少了脑萎缩，脑脊液递送也挽救了联合学习任务中的行为缺陷[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
基因 ID

4137  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

145 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

替拉奈单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Biological Activity
  • Immobilized Human Tau Protein (His Tag) can bind Tilavonemab. The EC50 for this effect is 2.182 ng/mL.
纯度 & 产品资料

纯度: 99.59%

COA (265 KB) SDS-PAGE (65 KB) SEC-HPLC (180 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Tilavonemab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tilavonemab2096513-89-0ABBV-8E12 C2N-8E12替拉奈单抗Tau Proteinalzheimer’s diseaseADtauneuronInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Tilavonemab
目录号：
HY-P99163
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z