2. Neuronal Signaling
  3. CaMK
  4. TIM-063

TIM-063 是一种选择性和细胞可渗透的 CaMKK 抑制剂，ATP 竞争性抑制剂，可以直接靶向 CaMKK 的催化结构域，作用于 CaMKKα 和CaMKKβ 的 Ki值分别是 0.35 μM 和 0.2 μM，IC50 值分别是 0.63 μM 和 0.96 μM。

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TIM-063 Chemical Structure

TIM-063 Chemical Structure

CAS No. : 2493978-38-2

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1 mg ￥1300
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5 mg ￥3400
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10 mg ￥5500
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TIM-063 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TIM-063 is a selective and cell-permeable CaMKK inhibitor, ATP competitive inhibitor, can directly target the catalytic domain of CaMKK, with the Ki values of 0.35 μM and 0.2 μM for CaMKKα and CaMKKβ, respectively, the IC50 values are 0.63 μM and 0.96 μM, respectively[1].

体外研究
(In Vitro)

TIM-063(0-29 μM, 6 h)可以剂量依赖性抑制 HeLa 细胞内源性 CaMKK 活性，也可以在转染的 COS-7 细胞中抑制 CaMKK 同种型催化的 CaMKIV 磷酸化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TIM-063 相关抗体:
分子量

331.28

Formula

C18H9N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TIM-063 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TIM-0632493978-38-2TIM063TIM 063CaMKCalmodulin-dependent protein kinasesCalmodulin-dependent kinasesCaMKKATPCaMKKαCaMKKβInhibitorinhibitorinhibit

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目录号：
HY-148757
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