1. Anti-infection Metabolic Enzyme/Protease
  2. HIV Protease
  3. TMC310911

TMC310911  (Synonyms: ASC-09)

目录号: HY-107123 纯度: 99.90%
COA 产品使用指南

TMC310911 是一种有效且具有口服活性的 HIV-1 蛋白酶抑制剂,对于野生型 HIV-1EC50 值范围为 2.2 nM 至 14.2 nM。TMC310911 对多种重组的 HIV-1 分离株也具有有效的活性,并具有很强的抗病毒活性。

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TMC310911 Chemical Structure

TMC310911 Chemical Structure

CAS No. : 1000287-05-7

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥2750
In-stock
1 mg ¥850
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5 mg ¥2500
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10 mg ¥4400
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25 mg ¥9300
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100 mg   询价  

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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TMC310911 is a potent and orally active HIV type-1 (HIV-1) protease inhibitor with EC50 values ranged from 2.2 nM to 14.2 nM for wild-type HIV-1. TMC310911 has potent activity against a wide spectrum of recombinant HIV-1 isolates. TMC310911 has strong antiviral activity[1][2].

IC50 & Target

EC50: 2.2-14.2 nM (Wild-type HIV-1)[1]

体外研究
(In Vitro)

For a panel of 2,011 recombinant isolates with decreased susceptibility to at least one of the currently approved protease inhibitors (PIs), the FC in TMC310911 EC50 is ≤4 for 82% of isolates and ≤10 for 96% of isolates. The fold change (FC) in TMC310911 EC50 is ≤4 and ≤10 for 72% and 94% of isolates with decreased susceptibility to Darunavir, respectively. In vitro resistance selection (IVRS) performed with r13025, a multiple-PI-resistant recombinant isolate, and TMC310911 selected for mutations L10F, I47V, and L90M (FC in TMC310911 EC50 = 16)[1].
The TMC310911 EC50 values against HIV-1/LAI and HIV-2/ROD in MT4 cells with EC50 values of 14.2 nM and 2 nM, respectively, and HIV-1/LAI and HIV-1/SF2 in PBMCs with EC50 values of 2.2 nM and 2.3 nM, respectively, and HIV-1/BaL in M/M cells with an EC50 value of 13.9 nM. And the corresponding EC90 values ranged from 5.0 to 94.7 nM. The TMC310911 CC50 for MT4 cells is 9.9 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
分子量

755.99

Formula

C38H53N5O7S2

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验: 

DMSO 中的溶解度 : 100 mg/mL (132.28 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3228 mL 6.6138 mL 13.2277 mL
5 mM 0.2646 mL 1.3228 mL 2.6455 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3228 mL 6.6138 mL 13.2277 mL 33.0692 mL
5 mM 0.2646 mL 1.3228 mL 2.6455 mL 6.6138 mL
10 mM 0.1323 mL 0.6614 mL 1.3228 mL 3.3069 mL
15 mM 0.0882 mL 0.4409 mL 0.8818 mL 2.2046 mL
20 mM 0.0661 mL 0.3307 mL 0.6614 mL 1.6535 mL
25 mM 0.0529 mL 0.2646 mL 0.5291 mL 1.3228 mL
30 mM 0.0441 mL 0.2205 mL 0.4409 mL 1.1023 mL
40 mM 0.0331 mL 0.1653 mL 0.3307 mL 0.8267 mL
50 mM 0.0265 mL 0.1323 mL 0.2646 mL 0.6614 mL
60 mM 0.0220 mL 0.1102 mL 0.2205 mL 0.5512 mL
80 mM 0.0165 mL 0.0827 mL 0.1653 mL 0.4134 mL
100 mM 0.0132 mL 0.0661 mL 0.1323 mL 0.3307 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
TMC310911
目录号:
HY-107123
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