1. GPCR/G Protein
  2. Adenosine Receptor
  3. Tonapofylline

Tonapofylline (Synonyms: BG 9928)

目录号: HY-14873 纯度: >98.0%
产品使用指南

Tonapofylline (BG 9928) 是一种具有口服活性和选择性 A1 腺苷受体拮抗剂,对人 A1 腺苷受体 (hA1) 的 Ki 为 7.4 nM,选择性高出 A2A 腺苷受体 915 倍,A2B 腺苷受体 12 倍,正在开发为治疗心力衰竭的药物。

MCE 的所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务

Tonapofylline Chemical Structure

Tonapofylline Chemical Structure

CAS No. : 340021-17-2

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

Size Price Stock Quantity
5 mg ¥3500 In-stock
10 mg ¥5300 Get quote
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

Description

Tonapofylline (BG 9928) is an orally active and selective adenosine A1 receptor antagonist with a Ki of 7.4 nM for human adenosine A1 receptor (hA1), which displays 915-fold selectivity versus human adenosine A2A receptor and 12-fold selectivity versus human adenosine A2B receptor and is used in development for the treatment of heart failure[1][2].

IC50 & Target

Ki: 7.4 nM (Human adenosine A1 receptor)[1]

In Vivo

Tonapofylline (BG 9928) (1 mg/kg; p.o., b.i.d, days 0-6) produces sustained reductions in post-Cisplatin serum creatinine and blood urea nitrogen levels, improves body weight recovery and significant attenuation of Cisplatin-induced (5.5 mg/kg) kidney pathology scores[3].

Animal Model: Female viral antigen-free Sprague-Dawley rats[3]
Dosage: 1 mg/kg
Administration: Oral administration; twice a day, days 0-6
Result: Produced sustained reductions in post-Cisplatin serum creatinine and blood urea nitrogen levels, improved body weight recovery and significant attenuation of Cisplatin-induced (5.5 mg/kg) kidney pathology scores.
Clinical Trial
Molecular Weight

416.51

Formula

C₂₂H₃₂N₄O₄

CAS No.

340021-17-2

SMILES

O=C(O)CCC1(CC2)CCC2(C(N3)=NC(N(CCC)C(N4CCC)=O)=C3C4=O)CC1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
Tonapofylline
目录号:
HY-14873
需求量:

Tonapofylline

Cat. No.: HY-14873