2. Cell Cycle/DNA Damage Anti-infection
  3. Topoisomerase Bacterial
  4. Topoisomerase IV inhibitor 2

Topoisomerase IV inhibitor 2 (compound 5d) 是一种有效的 DNA 拓扑异构酶 IV (TOPO IV) 抑制剂，对 TOPO IV 和 DNA 促旋酶的 IC50 分别为 0.35 μM 和 0.55 μM。Topoisomerase IV inhibitor 2 具有抗菌活性，对金黄色葡萄球菌 Nerman 菌株 (Staphylococcus aureus Newman) 和 大肠杆菌 (Escherichia coli) ATCC8739 的 MIC 分别为 1.985 μM 和 0.744 μM。

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Topoisomerase IV inhibitor 2 Chemical Structure

Topoisomerase IV inhibitor 2 Chemical Structure

CAS No. : 2883403-36-7

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  • 生物活性

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  • 参考文献

生物活性

Topoisomerase IV inhibitor 2 (compound 5d) is a potent DNA topoisomerase IV (TOPO IV) inhibitor with IC50s of 0.35 μM and 0.55 μM for TOPO IV and DNA gyrase, respectively. Topoisomerase IV inhibitor 2 has anti-bacterial activity, with MICs of 1.985 μM and 0.744 μM in Staphylococcus aureus Newman and Escherichia coli ATCC8739, respectively[1].

IC50 & Target

TOPO IV

0.35 μM (IC50)

分子量

671.70

Formula

C33H30FN7O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Topoisomerase IV inhibitor 2 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Topoisomerase IV inhibitor 22883403-36-7Topoisomerase IV inhibitor2Topoisomerase IV inhibitor-2TopoisomeraseBacterialAntibacterialStaphylococcus aureusEscherichia coliDNA gyraseInhibitorinhibitorinhibit

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