2. PROTAC Cell Cycle/DNA Damage
  3. Molecular Glues CDK DNA/RNA Synthesis
  4. TR-213

TR-213 是一种强效的分子胶降解剂，靶向细胞周期蛋白 K (CDK)。TR-213 在 1μM 的浓度下，可使 CDK12 和 Cyclin 分别减少 91% 和 56%。TR-213 能够抑制 RNA 聚合酶 II 的活性，并调控选择性多聚腺苷酸化 (APA) 活性。TR-213 可用于癌症研究。

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TR-213

TR-213 Chemical Structure

CAS No. : 2980502-40-5

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TR-213 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TR-213 is a potent molecular glue degrader that targets Cyclin K (CDK). TR-213 induces 91% and 56% decrease in CDK12 and Cyclin at 1 μM. TR-213 can inhibit RNA polymerase II activity and regulates alternative polyadenylation (APA) activity. TR-213 can be used for the research of cancer[1].

体外研究
(In Vitro)

TR-213 (0.1-10 μM, 6 h) 作用于 A549 和 U2OS 细胞，强效降解 Cyclin K 和 CDK12 (1 μM 时分别降解 56% 和 91%)，抑制 RNA 聚合酶 II Ser2 位点磷酸化，调节选择性多聚腺苷酸化活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TR-213 相关抗体:
分子量

388.42

Formula

C22H20N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TR-213 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TR-2132980502-40-5TR213TR 213Molecular GluesCDKDNA/RNA SynthesisCyclin dependent kinaseCyclin KRNA polymerase IIAPAcancerInhibitorinhibitorinhibit

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产品名称：
TR-213
目录号：
HY-177743
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