2. Apoptosis NF-κB
  3. Apoptosis Keap1-Nrf2
  4. Tricetin

Tricetin  (Synonyms: 三粒小麦黄酮)

目录号: HY-131592 纯度: 99.19%
COA 产品使用指南

摩尔计算器

Tricetin 是一种有效的竞争性 Keap1-Nrf2 蛋白相互作用 (PPI) 抑制剂。Tricetin 作用于帕金森病模型，通过激活 Nrf2/HO-1 信号通路和阻止线粒体依赖性细胞凋亡 (apoptosis) 通路来保护 6-OHDA 诱导的神经毒性。

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Tricetin Chemical Structure

Tricetin Chemical Structure

CAS No. : 520-31-0

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5 mg ￥3400
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Tricetin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tricetin is a potent competitive inhibitor of the Keap1-Nrf2 Protein Protein Interaction (PPI). Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway[1].

体外研究
(In Vitro)

Tricetin is mainly found in natural plants such as Ginkgo biloba L., Carica papaya L. and Murraya exotica L. Tricetin activates the Nrf2/HO-1 pathway to protect cells from oxidative stress. Tricetin possessed the protective effect on dopamine neurons of C. elegans. Tricetin has cytostatic properties and anti-metastatic activity of various solid tumors[1].
Pretreatment with Tricetin (20, 40, and 80 μM; for 4 hours) significantly improves 6-OHDA (200 μM)-induced SH-SY5Y cells viability and suppresses mitochondria-mediated apoptosis[1].
Tricetin (80 μM; for 1, 2 and 4 h) markedly decreased the expressions of p-JNK and p-p38[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tricetin 相关抗体:

Cell Viability Assay

Cell Line: SH-SY5Y cells
Concentration: 20, 40, and 80 μM
Incubation Time: Pretreatment for 4 h followed by 6-OHDA (200 μM) for 24 h
Result: Significantly increased 6-OHDA-induced SH-SY5Y cells viability.

Western Blot Analysis

Cell Line: SH-SY5Y cells
Concentration: 80 μM
Incubation Time: 1, 2 and 4 h
Result: Markedly decreased the expressions of p-JNK and p-p38. 
分子量

302.24

Formula

C15H10O7
CAS 号
性状

固体

颜色

Light yellow to brown

中文名称

三粒小麦黄酮
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 99.19%

COA (193 KB) LCMS (94 KB)

产品使用指南 (1538 KB)
参考文献

Tricetin 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tricetin520-31-0三粒小麦黄酮ApoptosisKeap1-Nrf2PPIcell viabilityapoptosisheme oxygenase-1Parkinson's diseaseInhibitorinhibitorinhibit

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