2. Cytoskeleton Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. Microtubule/Tubulin Apoptosis PARP Caspase
  4. Trilexium

Trilexium  (Synonyms: TRX-E-009-1)

目录号: HY-157800 纯度: 99.70%
COA 产品使用指南

摩尔计算器

Trilexium (TRX-E-009-1) 是第三代苯并吡喃，结构与 TRX-E-002-1 (HY-114250) 相关。Trilexium 增加 p21 蛋白表达并诱导细胞凋亡 (apoptosis)。Trilexium 解聚微管。Trilexium 显示出广泛的抗癌活性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Trilexium Chemical Structure

Trilexium Chemical Structure

CAS No. : 1983180-82-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Trilexium 相关抗体

Top Publications Citing Use of Products

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Trilexium (TRX-E-009-1) is a third-generation of benzopyran structurally related to TRX-E-002-1 (HY-114250). Trilexium increases p21 protein expression and induces apoptosis. Trilexium depolymerizes microtubules. Trilexium shows broad anti-cancer activity[1][2].

体外研究
(In Vitro)

Trilexium 显示出针对多种癌症类型的活性。 在 Eurofin 的 Oncopanel 中评估的 240 个细胞系中，有 10 个细胞系显示 IC50 > 30 μM，其余 230 个细胞系中，平均 IC50 为 0.428 μM< sup>[1]。
Trilexium (300 nM, 4 h) 会破坏 Hela 细胞中的微管网络[1]。
Trilexium (1-5 μM) 会导致 HSJD-DIPG007 细胞中 p21、c-PARP 和 c-Caspase 3 的蛋白表达增加[2]。
Trilexium (0-2 μM) 可恢复 HSJD-DIPG007 细胞中的 H3K27 三甲基化并增加 H3K27 乙酰化[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Trilexium 相关抗体:
体内研究
(In Vivo)

Trilexium (5-60 mg/kg，每天静脉注射，持续 15 天)可显著减少体内肿瘤体积[1]。
Trilexium (80 mg/kg，每天静脉注射，持续 5 天)会破坏体内微管[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57/BL6 mice (n = 8 mice per group, subcutaneous mouse xenograft model of BRAF mutant (BRAFV600E) melanoma (A375))[1]
Dosage: 5 and 60 mg/kg
Administration: IV (tail vein injection), daily for 15 days
Result: Resulted in a tumour growth inhibition at 60 mg/kg. Significantly improved survival at 60 mg/kg.
Animal Model: A375 xenografts mice[1].
Dosage: 80 mg/kg
Administration: IV, daily for 5 days
Result: Resulted in a loss of the long microtubule filaments in favour of shorter filaments and dispersed tubulin staining.
分子量

426.43

Formula

C24H23FO6
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献

Trilexium 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trilexium1983180-82-0TRX-E-009-1Microtubule/TubulinApoptosisPARPCaspasepoly ADP ribose polymeraseHSJD-DIPG007melanomaA375BRAFV600Eanti cancerInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Trilexium
目录号：
HY-157800
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z