2. Immunology/Inflammation Protein Tyrosine Kinase/RTK Membrane Transporter/Ion Channel Neuronal Signaling
  3. TREM receptor Syk Calcium Channel
  4. VHB937

VHB937 是一种人源单克隆抗体，可作为强效、选择性的 TREM2 激动剂，并具有亚纳摩尔级别的亲和力。VHB937 可增强 TREM2 的表面表达和其下游信号传导，例如 Syk 磷酸化与钙离子动员 (calcium mobilization)。VHB937 在多种神经炎症和神经退行性动物模型中均表现出显著的神经保护作用，可有效减轻病理损伤并降低促炎标志物水平。VHB937 可用于神经退行性疾病相关研究。

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VHB937

VHB937 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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VHB937 相关抗体

Top Publications Citing Use of Products

查看 TREM receptor 亚型特异性产品:

查看所有亚型
TREM-1 TREM-2

查看 Calcium Channel 亚型特异性产品:

查看所有亚型
N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VHB937 is a potent and selective TREM2 agonist, a human monoclonal antibody, with sub-nanomolar affinity. VHB937 enhances TREM2 surface expression and downstream signaling, such as Syk phosphorylation and calcium mobilization. VHB937 exhibits robust neuroprotective effects in vivo, significantly reducing pathology and pro-inflammatory markers across a broad range of animal models of neuroinflammation and neurodegeneration. VHB937 can be used for neurodegenerative diseases research[1].

IC50 & Target[1]

TREM-2

 

体外研究
(In Vitro)

VHB937 在具有内源性 TREM2 表达的人原代细胞中能够诱导 Syk 蛋白磷酸化并激活钙信号通路[1]。
VHB937 可增强小胶质细胞的关键功能，如趋化性与吞噬作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

VHB937 相关抗体:
体内研究
(In Vivo)

VHB937 在多种神经退行性疾病动物模型中，能促进神经元健康并改善星形胶质细胞增生，该作用通过诱导神经保护性小胶质细胞产生神经保护性表型实现，表明其功效超越了小胶质细胞本身[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VHB937 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VHB937VHB 937VHB-937TREM receptorSykCalcium ChannelTriggering receptors expressed on myeloid cellsSpleen tyrosine kinaseCa2+ channelsCa channelsTREM2surface expressionneuroprotectivepro-inflammatoryneuroinflammationneurodegenerationcalcium mobilizationInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-P991734
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