2. Stem Cell/Wnt
  3. sFRP-1 Wnt β-catenin
  4. WAY-362692

WAY-362692 是一种分泌型卷曲相关蛋白 (sFRP-1) 抑制剂 (IC50 值为 0.02 μM)，其作用靶点为 sFRP-1 的 netrin 结构域。WAY-362692 能够竞争性抑制 sFRP-1 与 Wnt 蛋白之间的相互作用，并激活 Wnt/β-catenin 信号通路 (EC50 值为 0.03 μM)。WAY-362692 能够激活成骨细胞并促进骨重塑。WAY-362692 可用于代谢性疾病的研究，如骨质疏松症。

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WAY-362692

WAY-362692 Chemical Structure

CAS No. : 915763-27-8

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WAY-362692 相关抗体

Top Publications Citing Use of Products

查看 Wnt 亚型特异性产品:

查看所有亚型
Wnt1 Wnt3 Wnt5 Wnt7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WAY-362692 is a secreted frizzled-related protein (sFRP-1) inhibitor (IC50 of 0.02 μM), targeting the netrin domain of sFRP-1. WAY-362692 can competitively inhibit the interaction between sFRP-1 and Wnt proteins, and activate the Wnt/β-catenin signaling pathway (EC50 = 0.03 μM). WAY-362692 can activate osteoblasts and promote bone remodeling. WAY-362692 can be used for the research of metabolic disease, such as osteoporosis[1].

体外研究
(In Vitro)

WAY-362692 (Compound 7b) (0.1-1 nM, 7 days) 可诱导 4 日龄新生小鼠颅骨的成骨细胞活化和骨重塑，并增加总骨面积[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

WAY-362692 相关抗体:
分子量

644.73

Formula

C28H35F3N4O6S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

WAY-362692 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WAY-362692915763-27-8WAY362692WAY 362692sFRP-1Wntβ-cateninSecreted frizzled related protein 1SARP-2FrzABeta cateninsecreted frizzled-related proteinWnt/β-cateninosteoblastsosteoporosisInhibitorinhibitorinhibit

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