2. Cytoskeleton
  3. Integrin
  4. XVA143

XVA143 是 α/β 样异构拮抗剂，抑制 LFA-1 依赖的稳固粘附，同时能增强剪切流和滚动的粘附作用。

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XVA143 Chemical Structure

XVA143 Chemical Structure

CAS No. : 264275-77-6

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规格 是否有货
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XVA143 相关抗体

Top Publications Citing Use of Products

查看 Integrin 亚型特异性产品:

查看所有亚型
αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

XVA143, an α/β I-like allosteric antagonist, inhibits LFA-1 dependent firm adhesion, while at the same time it enhances adhesion in shear flow and rolling both in vitro and in vivo[1].

体外研究
(In Vitro)

XVA143 (1 μM) completely abolishes binding of ICAM-1 to LFA-1 in Mn2+ and Mg2+/EGTA, with no hint of agonism[1]. XVA143 restores rolling of the αL-E310A β2 mutant by inducing extension of αL[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

XVA143 相关抗体:

Cell Viability Assay[1]

Cell Line: K562 cells.
Concentration: 0, 0.2, 0.5 and 1 μM.
Incubation Time:
Result: Potent against the weakest activator (2 mM Mg2+/1 mM EGTA, IC50 ~10-3 nM) and least potent against the strongest activator (1 mM Mn2+, IC50 ~10-3 nM).

Cell Viability Assay[1]

Cell Line: Wild-type murine lymphocytes[1].
Concentration: 100 μM.
Incubation Time:
Result: Induced a 50% increase in rolling fraction compared to vehicle-treated control cells ((from 27±5% to 41±7%).
分子量

562.36

Formula

C25H21Cl2N3O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

XVA143 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XVA143264275-77-6XVA 143XVA-143IntegrinICAM-1EGTALFA-1α/β IintegrinHIVInhibitorinhibitorinhibit

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产品名称：
XVA143
目录号：
HY-139202
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