2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. COX Lipoxygenase
  4. ZLJ-6

ZLJ-6 是一种具有口服活性的 COX 和 5-LOX 双重抑制剂，对 COX-1、COX-2 和 5-LOX 的 IC50 值分别为 0.73、0.31 和 0.99 μM。ZLJ-6 具有抗炎和镇痛活性。

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ZLJ-6 Chemical Structure

ZLJ-6 Chemical Structure

CAS No. : 1051931-39-5

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规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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ZLJ-6 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

查看 Lipoxygenase 亚型特异性产品:

查看所有亚型
5-LOX 12-LOX 15-LOX

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZLJ-6 is a dual COX and 5-LOX inhibitor with oral activity. The IC50 values for COX-1, COX-2 and 5-LOX were 0.73, 0.31 and 0.99 μM, respectively. ZLJ-6 has anti-inflammatory and analgesic activity[1][1].

IC50 & Target

COX-1

0.73 μM (IC50)

COX-2

0.31 μM (IC50)

5-LOX

0.99 μM (IC50)

体外研究
(In Vitro)

ZLJ-6 (3, 10, 30 μM, 6 h) 可有效抑制 TNF-α 诱导的单核细胞内皮相互作用和粘附分子 (e-选择素、ICAM-1 和 VCAM-1) 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ZLJ-6 相关抗体:

Western Blot Analysis[1]

Cell Line: HUVECs
Concentration: 3, 10, 30 μM
Incubation Time: 6 h
Result: Decreased NF-κB p65 subunit translocation to nucleus dose-dependently.
Inhibited TNF-α-induced IκBα phosphorylation.
体内研究
(In Vivo)

ZLJ-6 (3, 10, 30 mg/kg, 口服) 在卡拉胶导的大鼠足跖水肿模型中表现出有效的抗炎活性，在醋酸诱导的小鼠腹腔构建模型中表现出镇痛活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

375.42

Formula

C13H17N3O6S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ZLJ-6 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZLJ-61051931-39-5ZLJ6ZLJ 6COXLipoxygenaseCyclooxygenaseLOX5-LOXInhibitorHUVECsCarrageenaninhibitorinhibit

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产品名称：
ZLJ-6
目录号：
HY-113807
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