2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. α-Conotoxin RgIA

α-Conotoxin RgIA  (Synonyms: α-RgIA)

目录号: HY-P5845 纯度: 99.44%
COA 产品使用指南 技术支持

α-Conotoxin RgIA (α-RgIA) 是一种特异性的 α9α10 nAChR 拮抗剂。α-Conotoxin RgIA 可从 Conus regius 的毒液中分离得到。α-Conotoxin RgIA 可防止神经损伤引起的慢性疼痛的发生。α-Conotoxin RgIA 能够预防神经元和神经胶质的紊乱。α-Conotoxin RgIA 可显著减少水肿和炎性浸润，并防止髓鞘和纤维数量的损失。α-Conotoxin RgIA 用于神经系统疾病的研究。

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Custom Peptide Synthesis

α-Conotoxin RgIA

α-Conotoxin RgIA Chemical Structure

CAS No. : 876728-23-3

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规格 价格 是否有货 数量
1 mg ￥620
In-stock
5 mg ￥1550
In-stock
10 mg ￥2500
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

α-Conotoxin RgIA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

α-Conotoxin RgIA (α-RgIA) is a specific α9α10 nAChR antagonist. α-Conotoxin RgIA can be isolated from the venom of Conus regius. α-Conotoxin RgIA protects against the development of nerve injury-induced chronic pain. α-Conotoxin RgIA is able to prevent both neuronal and glial derangement. α-Conotoxin RgIA can significantly reduce edema and inflammatory infiltrate and prevent loss of myelin sheath as well as fiber number in vivo. α-Conotoxin RgIA is used in the study of neurological diseases[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Oocyte IC50
40 nM
Compound: RgIA
Inhibition of human alpha-9/rat alpha-10 nAChR expressed in Xenopus oocytes assessed as inhibition of acetylcholine-induced current by voltage clamp assay
Inhibition of human alpha-9/rat alpha-10 nAChR expressed in Xenopus oocytes assessed as inhibition of acetylcholine-induced current by voltage clamp assay
[PMID: 21888386]
体内研究
(In Vivo)

α-Conotoxin RgIA (Compound RglA) (2-10 nM，肌肉注射，每日一次，连续 14 天) 可预防 SD 大鼠的超敏反应并增加同侧爪子可耐受的重量[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male SD rats (200-250 g)[2]
Dosage: 2 and 10 nM
Administration: Intramuscular injection (i.m.)
Result: Relieved the postural imbalance by 62% and 74%.
Inhibited pain behavior induced by chronic constriction injury.
Preserved the nerve morphology.
Showed a higher number of fibers with respect to the vehicle-treated groups.
Significantly reduced the decreases in myelin thickness and axon diameter of the contralateral nerve and of the proximal portion of the ipsilateral nerve.
Significantly decreases the Iba1-positive cell density in the ipsilateral and contralateral horns.
分子量

1570.80

Formula

C59H95N25O18S4
CAS 号
性状

固体

颜色

White to off-white

Sequence

Gly-Cys-Cys-Ser-Asp-Pro-Arg-Cys-Arg-Tyr-Arg-Cys-Arg (Disulfide bridge:Cys2-Cys8;Cys3-Cys12)
Sequence Shortening

GCCSDPRCRYRCR (Disulfide bridge:Cys2-Cys8;Cys3-Cys12)
中文名称

α-芋螺毒素 RgIA
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (63.66 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6366 mL 3.1831 mL 6.3662 mL
5 mM 0.1273 mL 0.6366 mL 1.2732 mL
查看完整储备液配制表

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

α-Conotoxin RgIA 相关分类

完整储备液配制表

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6366 mL 3.1831 mL 6.3662 mL 15.9155 mL
5 mM 0.1273 mL 0.6366 mL 1.2732 mL 3.1831 mL
10 mM 0.0637 mL 0.3183 mL 0.6366 mL 1.5915 mL
15 mM 0.0424 mL 0.2122 mL 0.4244 mL 1.0610 mL
20 mM 0.0318 mL 0.1592 mL 0.3183 mL 0.7958 mL
25 mM 0.0255 mL 0.1273 mL 0.2546 mL 0.6366 mL
30 mM 0.0212 mL 0.1061 mL 0.2122 mL 0.5305 mL
40 mM 0.0159 mL 0.0796 mL 0.1592 mL 0.3979 mL
50 mM 0.0127 mL 0.0637 mL 0.1273 mL 0.3183 mL
60 mM 0.0106 mL 0.0531 mL 0.1061 mL 0.2653 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Conotoxin RgIA876728-23-3α-RgIAα-芋螺毒素 RgIAnAChRNicotinic acetylcholine receptorsConus regiusvenomneurological diseasesInhibitorinhibitorinhibit

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