1. GPCR/G Protein Neuronal Signaling
  2. mGluR
  3. 3,3'-Difluorobenzaldazine

3,3'-Difluorobenzaldazine  (Synonyms: DFB)

目录号: HY-14611
产品使用指南

3,3'-Difluorobenzaldazine (DFB) 是一种选择性 mGluR5 正变构调节剂。3,3'-Difluorobenzaldazine 可增强 mGlu5 激动剂 (Glutamate, Quisqualate, 3,5-Dihydroxyphenylglycine) 的 3-6 倍作用,EC50 在 2 到 5 μM 范围内。

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3,3'-Difluorobenzaldazine Chemical Structure

3,3'-Difluorobenzaldazine Chemical Structure

CAS No. : 15332-10-2

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  • 生物活性

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  • 参考文献

生物活性

3,3'-Difluorobenzaldazine (DFB) is a selective positive allosteric modulator of mGluR5. 3,3'-Difluorobenzaldazine potentiates 3- to 6-fold action for mGlu5 agonists (Glutamate, Quisqualate, and 3,5-Dihydroxyphenylglycine), with EC50s in the 2 to 5 μM range[1].

体外研究
(In Vitro)

3,3'-Difluorobenzaldazine (DFB) causes a concentration-dependent potentiation of the response of human mGluR5 CHO cells to 300 nM glutamate in this assay. The maximal potentiation at this concentration of glutamate is approximately 3.1-fold, with an EC50 for potentiation of 2.6 μM. 3,3'-Difluorobenzaldazine causes similar potentiation of the responses of both human mGluR5 and rat mGluR5 CHO cells to glutamate, quisqualate, and DHPG with comparable potencies[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

3,3'-Difluorobenzaldazine (40-100 nmol; icv) attenuates the locomotor hyperactivity, motor incoordination, and cognitive impairment induced by Ketamine[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male NMRI and ICR mice (8-9 weeks, 33-40 g)[2]
Dosage: 40-100 nmol (~9.7-24.4 μg)
Administration: ICV
Result: Attenuated the locomotor hyperactivity, motor incoordination, and cognitive impairment induced by Ketamine.
分子量

244.24

Formula

C14H10F2N2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

3,3'-Difluorobenzaldazine 相关分类

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3,3'-Difluorobenzaldazine
目录号:
HY-14611
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