2. Metabolic Enzyme/Protease GPCR/G Protein
  3. Endogenous Metabolite Adenosine Receptor
  4. 7-Methylxanthine

7-Methylxanthine  (Synonyms: 7-甲基黄嘌呤)

目录号: HY-W017163 纯度: ≥98.0%
COA 产品使用指南 技术支持

7-Methylxanthine 是一种具有口服活性的黄嘌呤甲基衍生物和非选择性腺苷受体拮抗剂。7-Methylxanthine 也是人尿结石的嘌呤成分之一。7-Methylxanthine 具有抗近视的活性。

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7-Methylxanthine

7-Methylxanthine Chemical Structure

CAS No. : 552-62-5

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7-Methylxanthine 相关抗体

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  • 生物活性

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生物活性

7-Methylxanthine is an orally active methyl derivative of xanthine and a non-selective adenosine receptor antagonist. 7-Methylxanthine is also one of the purine components of human urinary calculi. 7-Methylxanthine has anti-myopia activity[1][2].

IC50 & Target

Human Endogenous Metabolite

 

体内研究
(In Vivo)

7-Methylxanthine (100mg/kg；口服；每日两次；从 3 周龄开始至 147±4 天) 可改变幼年猕猴的正视化反应[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Macaca mulatta aged 2-3 weeks old were reared with -3D or +3D spectacle over their treated eyes and zero-powered lenses over their fellow eyes[2]
Dosage: 100 mg/kg
Administration: Oral administration, twice daily, from 24±2 days of age until 147±4 days of age
Result: Eliminated the consistent myopic anisometropia normally produced by -3D of imposed monocular defocus.
Caused compensating hyperopic anisometropias.
Changed the course of emmetropization in both the treated and fellow eyes of the lens-reared monkeys, resulting in more hyperopic refractive errors.
Led to a reduction in vitreous chamber elongation and an increase in choroidal thickness.
Clinical Trial
分子量

166.14

Formula

C6H6N4O2
CAS 号
性状

固体

颜色

White to light brown

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
纯度 & 产品资料

纯度: ≥99.0%

COA (288 KB)

产品使用指南 (1538 KB)
参考文献

7-Methylxanthine 相关分类

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Keywords:

7-Methylxanthine552-62-5Endogenous MetaboliteAdenosine ReceptorP1 receptormonkeyMyopia modelInhibitorinhibitorinhibit

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