1. Apoptosis MAPK/ERK Pathway
  2. Apoptosis JNK
  3. 8-Hydroxyefavirenz

8-Hydroxyefavirenz  (Synonyms: 8-OH-EFV)

目录号: HY-137397 纯度: 97.00%
COA 产品使用指南

8-Hydroxyefavirenz 是 Efavirenz (HY-10572) 的主要代谢物,8-Hydroxyefavirenz 通过 JNK 和 BimEL 依赖机制诱导原代人肝细胞凋亡 (apoptosis)。8-Hydroxyefavirenz 可用于癌症研究。

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8-Hydroxyefavirenz Chemical Structure

8-Hydroxyefavirenz Chemical Structure

CAS No. : 205754-33-2

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生物活性

8-Hydroxyefavirenz (8-OH-EFV) is a primary metabolite of (HY-10572). 8-Hydroxyefavirenz induces apoptosis via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. 8-Hydroxyefavirenz can be used in research of cancer[1]. 8-Hydroxyefavirenz is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

体外研究
(In Vitro)

8-Hydroxyefavirenz (8-OH-EFV; 1-10 μM; 3-24 h; 原代人肝细胞) 以时间和浓度依赖的方式增加细胞死亡,并从 6 小时开始诱导 caspase-3 活性[1]
8-Hydroxyefavirenz (1-10 μM; 6-24 h) 刺激原代人肝细胞中线粒体 ROS 的产生[1]
8-Hydroxyefavirenz (10 μM; 3-24 h) 激活 JNK 并使磷酸化的 JNK 占总 JNK 的比例增加 4.2 倍。8-Hydroxyefavirenz 增加 BimEL mRNA 和蛋白表达[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Primary human hepatocytes
Concentration: 1 and 10 μM
Incubation Time: 3, 6, 12 and 24 hours
Result: Increased cell death in a time- and concentration-dependent manner and increased cell death by 3.4-fold at 6 h.

Western Blot Analysis[1]

Cell Line: Primary human hepatocytes
Concentration: 1 and 10 μM
Incubation Time: 3, 6, 12 and 24 hours
Result: Increased the expression of cleaved caspase-3 in a time- and concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: Primary human hepatocytes
Concentration: 1 and 10 μM
Incubation Time: 3, 6, 12 and 24 hours
Result: Increased the phosphorylation of JNK and increased the mRNA and protein expression of BimEL.
分子量

331.67

Formula

C14H9ClF3NO3

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

8-Hydroxyefavirenz 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
8-Hydroxyefavirenz
目录号:
HY-137397
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