2. Stem Cell/Wnt TGF-beta/Smad
  3. PKA
  4. 8-pCPT-2'-O-Me-cAMP-AM

8-pCPT-2'-O-Me-cAMP-AM 

目录号: HY-107544 纯度: ≥99.0%
COA 产品使用指南

摩尔计算器

8-pCPT-2'-O-Me-cAMP-AM 是一类循环的 AMP 类似物，能够选择性激活 Epac-Rap 信号通路。8-pCPT-2'-O-Me-cAMP-AM 通过激活 Epack 可保护缺血损伤下的肾功能。8-pCPT-2'-O-Me-cAMP-AM 也通过与 PKA 通路相互作用刺激胰岛素分泌。

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8-pCPT-2'-O-Me-cAMP-AM Chemical Structure

8-pCPT-2'-O-Me-cAMP-AM Chemical Structure

CAS No. : 1152197-23-3

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规格 价格 是否有货 数量
100 μg ￥9700
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8-pCPT-2'-O-Me-cAMP-AM 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

8-pCPT-2'-O-Me-cAMP-AM is a cyclic AMP analogue, selectively activates Epac-Rap signaling pathway. 8-pCPT-2'-O-Me-cAMP-AM protects renal function by activating Epac from ischemia injury. 8-pCPT-2'-O-Me-cAMP-AM also stimulates insulin secretion by interaction with PKA pathway[1][2].

体外研究
(In Vitro)

8-pCPT-2'-O-Me-cAMP-AM (2.5 μM; 30 min) activates Epac and prevents adherens junction disassembly during hypoxia (60 min)[1].
8-pCPT-2'-O-Me-cAMP-AM can cross the plasma membrane and is able to alter diverse cellular functions that include Rap1 GTPase activity, PKB, and ERK1/2 protein kinase activity, phospholipase C activity, Ca2+ signaling, ion channel activity, exocytosis, cell adhesion, and gene expression[2].
8-pCPT-2'-O-Me-cAMP-AM stimulates insulin secretion with dose-dependent and glucose metabolism-dependent (0.1 or 1.11 mM) actions[2].
8-pCPT-2'-O-Me-cAMP-AM (20 μM) activates the cAMP reporter Epac1-camps, while 8-pCPT-2'-O-Me-cAMP doesn’t in INS-1 cells[2].
8-pCPT-2'-O-Me-cAMP-AM (0.3-3.0 μM; 0-300 sec) activates Epac1-camps in a dose- and time-dependent manner in high throughput assay[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

8-pCPT-2'-O-Me-cAMP-AM 相关抗体:
体内研究
(In Vivo)

8-pCPT-2'-O-Me-cAMP-AM (intrarenal injection; ) activates renal Rap1 and likely is caused by activation of Epac in the tubular epithelium[1].
8-pCPT-2'-O-Me-cAMP-AM preserves renal function by Epac activation and reduces tubular epithelial-cell stress during ischemia[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: IR injuried mouse model[1]
Dosage: 1.45 mM
Administration: Intrarenal injection; mice were sacrificed at 24, 48, or 72 hours after ischemia
Result: Protected renal injury during ischemia.
分子量

557.90

Formula

C20H21ClN5O8PS
CAS 号
性状

油状物

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

COA (272 KB)

产品使用指南 (1538 KB)
参考文献

8-pCPT-2'-O-Me-cAMP-AM 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8-pCPT-2'-O-Me-cAMP-AM1152197-23-3PKAProtein kinase Ainsulin secretioncyclic AMP analoguerenal functionRap1 GTPase activityPKBERK1/2 protein kinasephospholipase C activityCa2+ signalingion channel activityexocytosiscell adhesionInhibitorinhibitorinhibit

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