1. Epigenetics
  2. Histone Methyltransferase
  3. Dot1L-IN-1

Dot1L-IN-1 

目录号: HY-101520
产品使用指南

Dot1L-IN-1是高效,选择性,结构新颖的 Dot1L 抑制剂,Ki 为2 pM。

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Dot1L-IN-1 Chemical Structure

Dot1L-IN-1 Chemical Structure

CAS No. : 2088518-50-5

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dot1L-IN-1 is a highly potent, selective and structurally novel Dot1L inhibitor with a Ki of 2 pM.

IC50 & Target

Ki: 2 pM (Dot1L)[1]

体外研究
(In Vitro)

Dot1L-IN-1 potently suppresses H3K79 dimethylation (IC50 = 3 nM), the direct product of the Dot1Lcatalyzed reaction, as well as the activity of the HoxA9 promoter (IC50 = 17 nM) in HeLa and Molm-13 cells, respectively[1].

Dot1L-IN-1 effectively inhibits proliferation of the human MLL-rearranged leukemia cell line MV4-11 carrying the oncogenic MLL-AF4 fusion (IC50 = 5 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

646.21

Formula

C32H36ClN9O2S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
Dot1L-IN-1
目录号:
HY-101520
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