1. Metabolic Enzyme/Protease
  2. Cathepsin
  3. MIV-247

MIV-247是选择性的组织蛋白酶S (cathepsin S) 抑制剂,对人,小鼠和食蟹猴组织蛋白酶S的 Ki 值分别为2.1,4.2和7.5 nM。

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MIV-247 Chemical Structure

MIV-247 Chemical Structure

CAS No. : 1352817-76-5

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规格 价格 是否有货
1 mg ¥4000
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5 mg ¥9000
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Customer Review

MCE 顾客使用本产品发表的 1 篇科研文献

WB

    MIV-247 purchased from MCE. Usage Cited in: J Cell Physiol. 2021 Feb;236(2):1309-1320.  [Abstract]

    Western blots showing protein expression of cleaved caspase‐8, cleaved caspase‐3, and cleaved PARP in the myocardium of sham and myocardial I/R mice.
    • 生物活性

    • 实验参考方法

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    MIV-247 is a selective cathepsin S inhibitor with Kis of 2.1, 4.2 and 7.5 nM for human, mouse and cynomolgus monkey cathepsin S, respectively.

    IC50 & Target

    cathepsin S

     

    体内研究
    (In Vivo)

    Oral administration of MIV-247 (100-200 µmol/kg) dose-dependently attenuates mechanical allodynia by up to approximately 50% reversal when given as a single dose or when given twice daily for 5 days. Cathepsin S inhibition with MIV-247 exerts significant antiallodynic efficacy alone, and also enhances the effect of gabapentin and pregabalin without increasing side effects or inducing pharmacokinetic interactions[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    391.39

    Formula

    C17H24F3N3O4

    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    纯度 & 产品资料
    参考文献
    Animal Administration
    [1]

    Mice[1]

    MIV-247 is administered via oral gavage to Male C57BL/6 mice (20-30 g) at a dose volume of 5 ml/kg at doses up to 200 µmol/kg. In the PK studies, seven blood samples (20 µL) are drawn from the lateral saphenous vein of each mouse at 15 minutes, 30 minutes, 1 hour, 2 hours, 3 hours, 5 hours, and 7 hours postdose[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    参考文献

    MIV-247 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    产品名称:
    MIV-247
    目录号:
    HY-112583
    需求量: