2. Membrane Transporter/Ion Channel MAPK/ERK Pathway Stem Cell/Wnt NF-κB Apoptosis
  3. Sodium Channel MEK ERK NF-κB Apoptosis
  4. Lidocaine hydrochloride hydrate

Lidocaine hydrochloride hydrate  (Synonyms: 盐酸利多卡因; Lignocaine hydrochloride hydrate)

目录号: HY-B0185B
产品使用指南

摩尔计算器

Lidocaine (Lignocaine) hydrochloride hydrate 抑制涉及复杂电压和依赖性的钠通道 (sodium channels)。Lidocaine hydrochloride hydrate 通过调节 miR-145 表达和进一步抑制 MEK/ERK 和 NF-κB 信号通路来减少胃癌细胞的生长，迁移和侵袭。Lidocaine hydrochloride hydrate 是一种酰胺衍生物，可用于研究室性心律失常。

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Lidocaine hydrochloride hydrate Chemical Structure

Lidocaine hydrochloride hydrate Chemical Structure

CAS No. : 6108-05-0

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规格 价格 是否有货 数量
1 mg ￥100
1 周
5 mg ￥200
1 周
10 mg ￥250
1 周
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100 mg   询价  

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Customer Review

Other Forms of Lidocaine hydrochloride hydrate:

Lidocaine hydrochloride hydrate 相关抗体

Top Publications Citing Use of Products

    Lidocaine hydrochloride hydrate purchased from MCE. Usage Cited in: J Neuroinflammation. 2017 Nov 2;14(1):211.  [Abstract]

    Immunoblot results demonstrate that Lidocaine inhibits Morphine-induced upregulation of phosphorylation of p38 MAPK, but not the p38 total protein.

    查看 MEK 亚型特异性产品:

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    MEK1 MEK2 MEK5 MEK

    查看 ERK 亚型特异性产品:

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    ERK ERK1 ERK2 ERK5 ERK8

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    NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Lidocaine (Lignocaine) hydrochloride hydrate inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride hydrate decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride hydrate is an amide derivative and has potential for the research of ventricular arrhythmia[1][2].

    IC50 & Target[1][2]

    ERK

     

    NF-κB

     

    MEK

     

    体外研究
    (In Vitro)

    Lidocaine (Lignocaine) (10 nM; 48 hours) decreases significantly cell proliferation[2].
    Lidocaine (1-10 nM; 24-72 hours) inhibits cell viability and achieves the most suppressing effects at the concentration of 10 nM and treatment time 48 hours[2].
    Lidocaine (10 nM; 48 hours) increases significantly the apoptotic cell rate[2].
    Lidocaine (10 nM; 48 hours) down-regulates Cyclin D1 and up-regulates p21 expression significantly[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Lidocaine hydrochloride hydrate 相关抗体:

    Cell Proliferation Assay[2]

    Cell Line: The human gastric cancer cell line MKN45
    Concentration: 10 nM
    Incubation Time: 48 hours
    Result: Decreased significantly cell proliferation.

    Cell Viability Assay[2]

    Cell Line: The human gastric cancer cell line MKN45
    Concentration: 1, 5 and 10 nM
    Incubation Time: 24, 48, 72 hours
    Result: Inhibited MKN45 cell viability.

    Apoptosis Analysis[2]

    Cell Line: The human gastric cancer cell line MKN45
    Concentration: 10 nM
    Incubation Time: 48 hours
    Result: Increased significantly the apoptotic cell rate.

    Western Blot Analysis[2]

    Cell Line: The human gastric cancer cell line MKN45
    Concentration: 10 nM
    Incubation Time: 48 hours
    Result: Down-regulated Cyclin D1 and up-regulated p21 expression significantly.
    体内研究
    (In Vivo)

    Lidocaine (Lignocaine) causes completely reversible tail nerve block in rats. Mechanical nociception block produced by lidocaine has slower onset and faster recovery compared with thermal nociception block[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    分子量

    288.81

    Formula

    C14H25ClN2O2
    CAS 号
    中文名称

    盐酸利多卡因；盐酸赛罗卡因；盐酸赛洛卡因；盐酸昔罗卡因
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Lidocaine hydrochloride hydrate 相关分类

    • 摩尔计算器

    • 稀释计算器

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Lidocaine hydrochloride6108-05-0Lignocaine hydrochloride盐酸利多卡因盐酸赛罗卡因盐酸赛洛卡因盐酸昔罗卡因Sodium ChannelMEKERKNF-κBApoptosisNa channelsNa+ channelsMitogen-activated protein kinase kinaseMAPKKMAP2KExtracellular signal regulated kinasesNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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