1. Membrane Transporter/Ion Channel
    MAPK/ERK Pathway
    Stem Cell/Wnt
    NF-κB
  2. Sodium Channel
    MEK
    ERK
    NF-κB
  3. Lidocaine hydrochloride

Lidocaine hydrochloride (Synonyms: Lignocaine hydrochloride)

目录号: HY-B0185A 纯度: 99.95%
产品使用指南

Lidocaine hydrochloride (Lignocaine hydrochloride) 抑制涉及复杂电压和依赖性的钠通道 (sodium channels)。Lidocaine hydrochloride 通过调节 miR-145 表达和进一步抑制 MEK/ERKNF-κB 信号通路来减少胃癌细胞的生长,迁移和侵袭。Lidocaine hydrochloride 是一种常用的酰胺衍生物局部麻醉剂,一种治疗室性心律失常的药物和有效的肿瘤抑制剂。

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Lidocaine hydrochloride Chemical Structure

Lidocaine hydrochloride Chemical Structure

CAS No. : 73-78-9

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10 mM * 1 mL in Water ¥550 In-stock
5 g ¥500 In-stock
10 g ¥800 In-stock
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Other Forms of Lidocaine hydrochloride:

Top Publications Citing Use of Products

    Lidocaine hydrochloride purchased from MCE. Usage Cited in: J Neuroinflammation. 2017 Nov 2;14(1):211.

    Immunoblot results demonstrate that Lidocaine inhibits Morphine-induced upregulation of phosphorylation of p38 MAPK, but not the p38 total protein.

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    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    Description

    Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride is a commonly used local anesthetics of amide derivative, a drug to treat ventricular arrhythmia and an effective tumor-inhibitor[2].

    IC50 & Target[1,2]

    MEK

     

    ERK

     

    NF-κB

     

    In Vitro

    Lidocaine hydrochloride (Lignocaine hydrochloride) (10 nM; 48 hours) decreases significantly cell proliferation[2].
    Lidocaine hydrochloride (1-10 nM; 24-72 hours) inhibits cell viability and achieves the most suppressing effects at the concentration of 10 nM and treatment time 48 hours[2].
    Lidocaine hydrochloride (10 nM; 48 hours) increases significantly the apoptotic cell rate[2].
    Lidocaine hydrochloride (10 nM; 48 hours) down-regulates Cyclin D1 and up-regulates p21 expression significantly[2].

    Cell Proliferation Assay[2]

    Cell Line: The human gastric cancer cell line MKN45
    Concentration: 10 nM
    Incubation Time: 48 hours
    Result: Decreased significantly cell proliferation.

    Cell Viability Assay[2]

    Cell Line: The human gastric cancer cell line MKN45
    Concentration: 1, 5 and 10 nM
    Incubation Time: 24, 48, 72 hours
    Result: Inhibited MKN45 cell viability.

    Apoptosis Analysis[2]

    Cell Line: The human gastric cancer cell line MKN45
    Concentration: 10 nM
    Incubation Time: 48 hours
    Result: Increased significantly the apoptotic cell rate.

    Western Blot Analysis[2]

    Cell Line: The human gastric cancer cell line MKN45
    Concentration: 10 nM
    Incubation Time: 48 hours
    Result: Down-regulated Cyclin D1 and up-regulated p21 expression significantly.
    In Vivo

    Lidocaine hydrochloride (Lignocaine hydrochloride) causes completely reversible tail nerve block in rats. Mechanical nociception block produced by lidocaine has slower onset and faster recovery compared with thermal nociception block[3].

    Clinical Trial
    Molecular Weight

    270.80

    Formula

    C₁₄H₂₃ClN₂O

    CAS No.

    73-78-9

    SMILES

    O=C(NC1=C(C)C=CC=C1C)CN(CC)CC.[H]Cl

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    H2O : ≥ 36 mg/mL (132.94 mM)

    * "≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.6928 mL 18.4638 mL 36.9276 mL
    5 mM 0.7386 mL 3.6928 mL 7.3855 mL
    10 mM 0.3693 mL 1.8464 mL 3.6928 mL
    * 请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液,并请注意储备液的保存方式和期限。
    References
    • 摩尔计算器

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    The dilution calculator equation

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
    C1   V1   C2   V2

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    Inquiry Information

    产品名称:
    Lidocaine hydrochloride
    目录号:
    HY-B0185A
    需求量:

    Lidocaine hydrochloride

    Cat. No.: HY-B0185A