1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Pyruvate Kinase

Pyruvate Kinase

Pyruvate kinase is an enzyme that catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate and ATP in glycolysis and plays a role in regulating cell metabolism. There are four mammalian pyruvate kinase isoforms (PKM1, PKM2, PKR, PKL), and each isoform has had multiple designations over time in the literature. The M2 isoform of pyruvate kinase (PKM2) supports anabolic metabolism and is expressed both in cancer and normal tissue. The enzymatic activity of PKM2 is allosterically regulated by both intracellular signaling pathways and metabolites; PKM2 thus integrates signaling and metabolic inputs to modulate glucose metabolism according to the needs of the cell.

Pyruvate Kinase 相关产品 (7):

Cat. No. Product Name Effect Purity
  • HY-18657
    TEPP-46 Activator 99.71%
    TEPP-46 是一种有效,选择性的丙酮酸激酶 M2 (pyruvate kinase M2; PKM2) 激活剂,AC50 值为 92 nM,对 PKM1,PKL 和 PKR 作用较小或没有作用。
  • HY-N0822
    Shikonin Inhibitor 99.80%
    Shikonin 是中草药紫草的主要成分。Shikonin 是一种有效的 TMEM16A 氯化物通道 (chloride channel) 抑制剂,IC50 为 6.5 μM。Shikonin 是一种特异的丙酮酸激酶 M2 (PKM2) 抑制剂,还可以抑制 TNF-αNF-κB途径。
  • HY-19330
    DASA-58 Activator 99.79%
    DASA-58是有效的丙酮酸激酶M2 (PKM2) 活化剂,其中AC90AC50分别为680 nM,38 nM。
  • HY-103617
    PKM2-IN-1 Inhibitor
    PKM2-IN-1 是一种丙酮酸激酶 M2 (PKM2) 抑制剂,其 IC50 值为 2.95 μM。
  • HY-12689
    Mitapivat Activator 99.97%
    Mitapivat 是一种丙酮酸激酶 M2 型同工酶 (PKM2) 激活剂。
  • HY-135884
    PKR activator 2 Activator
    PKR activator 2 是一种有效的丙酮酸激酶 R (PKR) 激活剂,详细信息请参考专利文献 WO2019035863A1 中的化合物 385。
  • HY-135883
    PKR activator 1 Activator
    PKR activator 1 是一种有效的丙酮酸激酶 R (PKR) 激活剂,详细信息请参考专利文献 WO2019035865A1 中的化合物 E7-93。
Isoform Specific Products

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