2. NF-κB MAPK/ERK Pathway Autophagy Metabolic Enzyme/Protease
  3. NF-κB JNK Autophagy Endogenous Metabolite
  4. Tomatidine hydrochloride

Tomatidine hydrochloride  (Synonyms: 盐酸番茄碱)

目录号: HY-N2149A 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Tomatidine hydrochloride 通过阻断 NF-κB 和 JNK 信号发挥抗炎作用。Tomatidine hydrochloride 激活哺乳动物细胞或秀丽隐杆线虫中的自噬 (autophagy)。

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Tomatidine hydrochloride Chemical Structure

Tomatidine hydrochloride Chemical Structure

CAS No. : 6192-62-7

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规格 价格 是否有货 数量
5 mg ￥500
In-stock
10 mg ￥700
In-stock
25 mg ￥1400
In-stock
50 mg ￥2200
In-stock
100 mg ￥3500
In-stock
200 mg   询价  
500 mg   询价  

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Customer Review

Other Forms of Tomatidine hydrochloride:

Tomatidine hydrochloride 相关抗体

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Top Publications Citing Use of Products

    Tomatidine hydrochloride purchased from MCE. Usage Cited in: FASEB J. 2019 Feb;33(2):2574-2586.  [Abstract]

    Tomatidine attenuates osteoclastogenesis by inhibiting the MAPK, NF-kB, and PI3K/Akt signaling pathways in vitro.

    查看 NF-κB 亚型特异性产品:

    查看所有亚型
    NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

    查看 JNK 亚型特异性产品:

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    JNK1 JNK2 JNK3 JNK

    • 生物活性

    • 实验参考方法

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling[1]. Tomatidine hydrochloride activates autophagy either in mammal cells or C elegans[2].

    IC50 & Target[1]

    p65

     

    JNK

     

    体外研究
    (In Vitro)

    Tomatidine decreases inducible NO synthase and COX-2 expression through suppression of I-κBα phosphorylation, NF-κB nuclear translocation and JNK activation, which in turn inhibits c-jun phosphorylation and Oct-2 expression. Tomatidine, solasodine and diosgenin (40 μM) show 66%, 22% and 41% inhibition of nitrite production, respectively. The iNOS protein is barely detectable in unstimulated cells but markedly increases after LPS treatment, and Tomatidine causes dose-dependent inhibition of LPS-induced iNOS expression. p65 is the major component of NF-κB in LPS-stimulated macrophages, the effect of Tomatidine on p65 DNA-binding activity is determined. In the presence of Tomatidine at 10-40 μM, the binding activity of NF-κB is suppressed in a dose-dependent manner. Tomatidine inhibits the phosphorylation of I-κB, blocks the I-κB production, and furthermore suppresses p65 NF-κB translocation to the nucleus and modulated binding activity[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Tomatidine hydrochloride 相关抗体:
    分子量

    452.11

    性状

    固体

    Formula

    C27H46ClNO2
    CAS 号
    中文名称

    盐酸番茄碱
    结构分类
    初始来源
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    溶解性数据
    In Vitro: 

    DMSO 中的溶解度 : 5 mg/mL (11.06 mM; ultrasonic and adjust pH to 9 with NaOH; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    Ethanol 中的溶解度 : 3.45 mg/mL (7.63 mM; 超声助溶)

    H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.2119 mL 11.0593 mL 22.1185 mL
    5 mM 0.4424 mL 2.2119 mL 4.4237 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料

    纯度: ≥98.0%

    COA (268 KB) HNMR (300 KB) MS (68 KB)

    产品使用指南 (1538 KB)
    参考文献
    Cell Assay
    [1]

    RAW 264.7 cells, derived from murine macrophages, are cultured in DMEM supplemented with 10% endotoxin-free, heat-inactivated fetal calf serum, Penicillin (100 units/mL), and Streptomycin (100 μg/mL) in a 5% CO2 atmosphere at 37 °C in a humidified incubator. For all assay, cell is plated at 2×105 cells/cm2 in culture dishes or plates. Treatment with vehicle (0.1% DMSO or 0.1% ethanol), test compounds and/or LPS is carried out under serum-free conditions[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    参考文献

    Tomatidine hydrochloride 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    Ethanol / DMSO 1 mM 2.2119 mL 11.0593 mL 22.1185 mL 55.2963 mL
    5 mM 0.4424 mL 2.2119 mL 4.4237 mL 11.0593 mL
    DMSO 10 mM 0.2212 mL 1.1059 mL 2.2119 mL 5.5296 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Tomatidine6192-62-7盐酸番茄碱NF-κBJNKAutophagyEndogenous MetaboliteNuclear factor-κBNuclear factor-kappaBc-Jun N-terminal kinaseanti-inflammatorychemopreventionLPS-stimulatedmousemacrophagesphosphorylationInhibitorinhibitorinhibit

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    目录号：
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