2. GPCR/G Protein
  3. Angiotensin Receptor
  4. Valsartan-d9

Valsartan-d9  (Synonyms: 缬沙坦 D9; CGP 48933-d9)

目录号: HY-18204S 纯度: 99.33%
COA 产品使用指南

摩尔计算器

Valsartan-d9 是 Valsartan 氘代化合物。Valsarta 是血管紧张素 II 受体拮抗剂，有潜力用于高血压和心力衰竭的研究。

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Valsartan-d<sub>9</sub> Chemical Structure

Valsartan-d9 Chemical Structure

CAS No. : 1089736-73-1

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1 mg ￥2900
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Other Forms of Valsartan-d9:

Valsartan-d9 相关抗体

Top Publications Citing Use of Products

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AT1 Receptor AT2 Receptor

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Valsartan-d9 is deuterium labeled valsartan. Valsartan is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research[1].

IC50 & Target

AT1 Receptor

 

体外研究
(In Vitro)

Valsartan is a synthetic non-peptide angiotensin II type 1 receptor antagonist that dilates blood vessels and reduces blood pressure by blocking the action of angiotensin. Valsartan significantly decreases the expression of AT1R in ageing aorta endothelial cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Valsartan-d9 相关抗体:
分子量

444.57

Formula

C24H20D9N5O3
CAS 号
性状

固体

颜色

White to yellow

中文名称

缬沙坦 d9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 99.33%

COA (274 KB) LCMS (95 KB)

产品使用指南 (1538 KB)
参考文献
Animal Administration
[4]

Rats: Rats are randomly divided into two groups: (i) valsartan-treated group that is given intravenously 3 mg/kg/day valsartan in 0.5 mL normal saline via the vein daily for 1 week; (ii) hydralazine-treated group receiving 0.2 mg/kg/day hydralazine injection in saline; and (iii) control group that receives saline injection in the same way (n=15 for each group)[4].

Mice: Valsartan is dissolved in water containing 0.5% methylcellulose solution. Valsartan (5-40 mg/kg/d) is administered by oral (p.o.) route in a volume of 10 mL/kg body weight using the gavage technique. Potential alteration in blood pressure in response to chronic treatment with valsartan is assessed with a commercial blood pressure analysis systemdesigned. The mice are trained for at least 2 consecutive days to adapt to the apparatus before the study is initiated. To record the blood pressure, the mice are placed on a heated pad (35°C) and measured with a programmable tail-cuff sphygmomanometer in steady state. The average of 10 readings from each mouse is recorded[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Valsartan-d9 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Valsartan-d91089736-73-1CGP 48933-d9缬沙坦 d9Angiotensin ReceptorInhibitorinhibitorinhibit

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目录号：
HY-18204S
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