Ajmalicine hydrochloride  (Synonyms: Raubasine hydrochloride)

Ajmalicine (Raubasine) hydrochloride is a potent adrenolytic agent which preferentially blocks α₁-adrenoceptor. Ajmalicine hydrochloride is an reversible but non-competitive nicotine receptor full inhibitor, with an IC₅₀ of 72.3 μM. Ajmalicine hydrochloride also can be used as anti-hypertensive, and serpentine, with sedative activity^[1][2].

Ajmalicine hydrochloride preferentially blocks α₁-adrenoceptor than α₂-adrenoceptor^[1].
Ajmalicine hydrochloride inhibits contractions in a concentration-dependent manner (IC₅₀=72.3 ± 22.5 μM)^[2].
Ajmalicine hydrochloride acts preferentially at postsynaptic sites, competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptor with a pA2 value of 6.57, blocks the inhibitory effect of clonidine with an pA2 value of 6.2^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ajmalicine hydrochloride blocking the pressor action of electrical stimulation and is active against sympathetic stimulation^[1].
Ajmalicine hydrochloride (0.5-4 mg/kg) induces a marked dose-dependent inhibition against the pressor response to noradrenaline^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

388.89

C₂₁H₂₅ClN₂O₃

4373-34-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Roquebert J, et al. Inhibition of the alpha 1 and alpha 2-adrenoceptor-mediated pressor response in pithed rats by raubasine, tetrahydroalstonine and akuammigine. Eur J Pharmacol. 1984 Oct 30;106(1):203-5.  [Content Brief]

  [2]. Pereira DM, et al. Pharmacological effects of Catharanthus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission. Phytomedicine. 2010 Jul;17(8-9):646-52.  [Content Brief]

  [3]. Demichel P, et al. Effects of raubasine stereoisomers on pre- and postsynaptic alpha-adrenoceptors in the rat vas deferens. Br J Pharmacol. 1984 Oct;83(2):505-10  [Content Brief]