1. Metabolic Enzyme/Protease
    Autophagy
  2. Glucosidase
    Autophagy
  3. Ambroxol hydrochloride

Ambroxol hydrochloride (Synonyms: NA-872 hydrochloride)

目录号: HY-B1039A 纯度: >98.0%
产品使用指南

Ambroxol hydrochloride (NA-872 hydrochloride) 是前药溴己辛的活性代谢产物,具有强效祛痰作用。Ambroxol hydrochloride 是一种葡糖脑苷脂酶 (GCase) 伴侣,可增加葡糖脑苷脂酶的活性。Ambroxol hydrochloride 可诱导肺自噬,并有用于帕金森氏病和神经性戈谢病研究的潜力。

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Ambroxol hydrochloride Chemical Structure

Ambroxol hydrochloride Chemical Structure

CAS No. : 23828-92-4

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Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in Water ¥550 In-stock
100 mg ¥500 In-stock
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500 mg   Get quote  

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Description

Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the prodrug Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research[1][2].

In Vivo

Ambroxol hydrochloride (NA-872 hydrochloride; 1, 3, 4, 5 mM for 12 consecutive days in drinking water) results in increased brain glucocerebrosidase activity in wild-type mice, transgenic mice expressing the heterozygous L444P mutation in the murine glucocerebrosidase 1 gene, and transgenic mice overexpressing human α-synuclein[2].

Molecular Weight

414.56

Formula

C₁₃H₁₉Br₂ClN₂O

CAS No.

23828-92-4

中文名称

盐酸氨溴索

SMILES

O[C@H]1CC[C@H](NCC2=CC(Br)=CC(Br)=C2N)CC1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 8.33 mg/mL (20.09 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4122 mL 12.0610 mL 24.1220 mL
5 mM 0.4824 mL 2.4122 mL 4.8244 mL
10 mM 0.2412 mL 1.2061 mL 2.4122 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。 -80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

References
  • 摩尔计算器

  • 稀释计算器

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

AmbroxolNA-872NA872NA 872GlucosidaseAutophagyBromhexineexpectorantglucocerebrosidaseGCasechaperoneParkinsonneuronopathicGaucherdiseaseInhibitorinhibitorinhibit

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产品名称:
Ambroxol hydrochloride
目录号:
HY-B1039A
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