Anti-Mouse IL-18 Antibody (YIGIF74-1G7) 

Anti-Mouse IL-18 Antibody (YIGIF74-1G7) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IL-18. Anti-Mouse IL-18 Antibody (YIGIF74-1G7) can neutralize IL-18. Anti-Mouse IL-18 Antibody (YIGIF74-1G7) can be used for the researches of cancer, infection, inflammation and immunology, such as hepatocellular carcinoma and eosinophilic esophagitis^[1][2][3].

Rat IgG2a kappa

Rat IgG2a kappa, Isotype Control

Mouse

IL-18

Anti-Mouse IL-18 Antibody (YIGIF74-1G7) (5 μg/mL) 可中和树突状细胞中的 IL-18^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse IL-18 Antibody (YIGIF74-1G7) (首次 200 μg，之后每周 100 μg，腹腔注射) 在肝细胞癌小鼠模型中显示出抗肿瘤作用^[1]。
Anti-Mouse IL-18 Antibody (YIGIF74-1G7) (200 μg，感染前给药 3 次) 显著降低了鼠伤寒沙门氏菌感染小鼠中穆氏拟杆菌定殖的保护作用^[2]。
Anti-Mouse IL-18 Antibody (YIGIF74-1G7) (200 μg，腹腔注射，每周两次，共 3 周) 在嗜酸性食管炎小鼠模型中显示出抗炎作用^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

16173  [NCBI]

P70380

ELISA, FACS, Functional assay, Research in vivo

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

液体

Colorless to light yellow

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Goulet DR, Atkins WM. Considerations for the Design of Antibody-Based Therapeutics. J Pharm Sci. 2020 Jan;109(1):74-103.  [Content Brief]

  [2]. Molgora M, et al. IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity. Nature. 2017 Nov 2;551(7678):110-114.  [Content Brief]

  [3]. Chudnovskiy A, et al. Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome. Cell. 2016 Oct 6;167(2):444-456.e14.  [Content Brief]

  [4]. Yadavalli CS, et al. Allergen-induced NLRP3/caspase1/IL-18 signaling initiate eosinophilic esophagitis and respective inhibitors protect disease pathogenesis. Commun Biol. 2023 Jul 31;6(1):763.  [Content Brief]