2. Immunology/Inflammation NF-κB Anti-infection
  3. Interleukin Related NF-κB Parasite
  4. Anti-Mouse IL-9 Antibody (9C1)

Anti-Mouse IL-9 Antibody (9C1) 

目录号: HY-P990208 纯度: 95.00%
COA 技术支持

Anti-Mouse IL-9 Antibody (9C1) 是一种抗小鼠 IL-9 IgG2a 单克隆抗体。Anti-Mouse IL-9 Antibody (9C1) 可以减少 NF-κB 信号通路的激活并减少炎性细胞的浸润。Anti-Mouse IL-9 Antibody (9C1) 能有效降低 Th9 细胞介导的过敏反应和抗肿瘤作用。Anti-Mouse IL-9 Antibody (9C1) 可用于研究炎症疾病、感染疾病和癌症，如寄生虫感染、过敏反应、乳腺癌和骨肉瘤。

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Anti-Mouse IL-9 Antibody (9C1)

Anti-Mouse IL-9 Antibody (9C1) Chemical Structure

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Anti-Mouse IL-9 Antibody (9C1) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse IL-9 Antibody (9C1) is an anti-mouse IL-9 IgG2a monoclonal antibody. Anti-Mouse IL-9 Antibody (9C1) can reduce the activation of NF-κB signaling pathway and decrease the infiltration of inflammatory cells. Anti-Mouse IL-9 Antibody (9C1) effectively reduces Th9 cell-mediated allergic reactions and anti-tumor effects. Anti-Mouse IL-9 Antibody (9C1) can be used for researches on inflammation, infection conditions and cancer such as parasitic infections, allergic reactions, breast cancer and osteosarcoma[1][2][3][4].

同型

Mouse IgG2a kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target[1]

NF-κB

 

IL-9

 

体内研究
(In Vivo)

Anti-Mouse IL-9 Antibody (9C1) (100 μg，腹腔注射，每 3 天一次，持续 12 周) 可减少寄生虫感染模型雌性 BALB/c 小鼠炎症通路的激活，但会加剧寄生虫增殖。
Anti-Mouse IL-9 Antibody (9C1) (100 μg，腹腔注射，每日一次，持续 5 天) 有效阻断具有过敏反应的 C57BL/6 小鼠的 Th9 细胞介导的过敏炎症反应[2]。
Anti-Mouse IL-9 Antibody (9C1) (100 μg，腹腔注射，每 2 天一次，直到实验结束) 显著降低了携带 K7M2 或 4T1 肿瘤的 BALB/c 小鼠中 Th9 细胞的抗肿瘤作用[3]。
Anti-Mouse IL-9 Antibody (9C1) (0.5 mg，腹腔注射，每日一次，从第 -1 天至第 8 天) 可以改善感染伯氏疟原虫 ANKA 的雄性瑞士白化小鼠的寄生虫血症[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 2000 Echinococcus granulosus injected female BALB/c mice (8-10 weeks, 20 g)[1]
Dosage: 100 μg
Administration: Intraperitoneal injection (i.p.), once every 3 days, for 12 weeks
Result: Significantly reduced the mRNA levels of TLR2, NF-κB and IL-9.
Reduced inflammatory cell infiltration and fibrosis.
Exacerbated parasite proliferation and liver damage.
Animal Model: Ovalbumin (OVA) (HY-P0286) (100 μg) and TSLP (HY-P70818) (200 ng) induced C57BL/6 mice[2]
Dosage: 100 μg
Administration: Intraperitoneal injection (i.p.), once daily, for 5 days
Result: Significantly reduced pulmonary eosinophil infiltration and inflammatory response.
Animal Model: 1×105 K7M2 or 4T1 cells injected BALB/c mice[3]
Dosage: 100 μg
Administration: Intraperitoneal injection (i.p.), once every 2 days, until the end of the experiment
Result: Significantly reduced the inhibitory effect of Th9 cells on tumor lung metastasis.
Animal Model: 1×106 infected red blood cells injected male Swiss Albino mice (6-8 weeks, 25 g)[4]
Dosage: 0.5 mg
Administration: Intraperitoneal injection (i.p.), once daily, from day -1 to day 8
Result: Significantly increased mouse survival rate to 66.67 %.
Reduced parasitic infections and neurological symptom scores.
Reduced Th17 cell frequency and improved Th17/Treg ratio imbalance.
Downregulated the expression of pro-inflammatory cytokines such as IL-6 and IL-1β.
基因 ID

16198  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (267 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse IL-9 Antibody (9C1) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-9 Antibody (9C1)Interleukin RelatedNF-κBParasiteILNuclear factor-κBNuclear factor-kappaBIL-9allergic reactionsparasitic4T1K7M2Inhibitorinhibitorinhibit

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