1. Immunology/Inflammation
  2. Transmembrane Glycoprotein
  3. Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1)

Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) 

目录号: HY-P990168
技术支持

Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) 是一种源自叙利亚仓鼠的 IgG 型抗体抑制剂,靶向小鼠 Podoplanin/glycoprotein 38。Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) 可阻断 Podoplanin 与 C 型凝集素受体 CLEC-2 的结合。Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) 可用于癌症和炎症的研究,如肺炎。

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Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1)

Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) Chemical Structure

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) is a Syrian hamster-derived IgG type antibody inhibitor, targeting to mouse Podoplanin/glycoprotein 38. Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) blocks podoplanin binding to C-type lectin receptor CLEC-2. Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) can be used for the research of cancer and inflammation, such as lung inflammation[1][2].

同型

Syrian hamster IgG

反应种属

Mouse

IC50 & Target

Podoplanin/glycoprotein 38

体外研究
(In Vitro)

Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) (10 μg/mL, 24 h) 可减少成纤维网状细胞 (FRCs) 的覆盖面积[1]
Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) (10 μg/mL, 24 h) 可降低脂多糖 ( HY-D1056) 处理的肺泡巨噬细胞中 iNOS 的表达以及 IL-6、CXCL12 和 TNF-α 的水平[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) (100 μg,静脉注射,单剂量) 可减轻小鼠成纤维网状细胞 (FRCs) 的收缩[1]
Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) (100 μg/mouse,静脉注射, LPS 刺激后 6 小时) 可减轻脂多糖 (HY-D1056) 诱导的肺部炎症模型小鼠中的中性粒细胞浸润,并改善肺功能下降[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild type mice or Ccl19-Cre+Rosa26-eYFPfl/fl mice[1]
Dosage: 100 μg
Administration: Intravenously injection
Result: Showed no bleeding and inflammation, or major disorganization of lymphocytes.
Enlarged skin-draining LNs and reduced stiff.
Increased total FRC numbers and f BrdU+ FRCs numbers.
Expanded FRC network.
Increased OT-I T cell numbers 96 h after immunization with LPS ( HY-D1056) and OVA and reduced T cells.
Animal Model: LPS ( HY-D1056)-induced lung inflammation mice models[2]
Dosage: 100 μg/mouse
Administration: Intravenously injection, 6 h afte LPS
Result: Reduced arterial O2 saturation decline.
Showed increased activity and weight gain.
Reduced neutrophil infiltration and numbers.
Reduced total BAL protein and IL-6 levels.
基因 ID

14726  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo

偶联物

Unconjugated

复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.

分子量

150 kDa

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1)
目录号:
HY-P990168
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