2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Apoptosis Bcl-2 Family Caspase Reactive Oxygen Species
  4. Anticancer agent 56

Anticancer agent 56 (compound 4d) 是一种具有类似活性分子特性的强效抗癌剂，对多种肿瘤细胞系具有抗癌活性 (IC50<3 μM)。Anticancer agent 56 诱导细胞周期阻滞在 G2/M 期，并触发线粒体凋亡通路。Anticancer agent 56 通过积累 ROS，上调 BAX，下调 Bcl-2，激活 caspases 3, 7, 9 起到抗癌作用。

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Anticancer agent 56 Chemical Structure

Anticancer agent 56 Chemical Structure

CAS No. : 2241915-59-1

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Anticancer agent 56 相关抗体

Top Publications Citing Use of Products

查看 Bcl-2 Family 亚型特异性产品:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 56 (compound 4d) is a potent anti-cancer agent with agent-likeness properties, possessing anticancer activity against several cancer cell lines (IC50<3 μM). Anticancer agent 56 induces cell cycle arrest at G2/M phase and triggers mitochondrial apoptosis pathway. Anticancer agent 56 acts by accumulation of ROS, up regulation of BAX, down regulation of Bcl-2 and activation of caspases 3, 7, 9[1].

IC50 & Target

IC50: 0.64 ± 0.02 μM in Leukemia RPMI-8226, 0.96 ± 0.04 μM in Leukemia SR, 0.84 ± 0.07 μM in Leukemia K-562, 0.69 ± 0.01 μM in Melanoma M14, 0.24 ± 0.01 μM in Breast MCF7, 0.26 ± 0.01 μM in Colon HCT116, 2.95 ± 0.14 μM in Prostate PC3[1]
分子量

383.83

Formula

C20H18ClN3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 56 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 562241915-59-1Anticancer agent56Anticancer agent-56ApoptosisBcl-2 FamilyCaspaseReactive Oxygen SpeciesAnticancerMitochondrial apoptotic pathwayRPMI-8226SRK-562M14MCF7HCT116PC3Inhibitorinhibitorinhibit

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