2. Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. Apoptosis Caspase PARP Bcl-2 Family
  4. Apoptosis inducer 45

Apoptosis inducer 45 是一种凋亡 (apoptosis) 诱导剂。Apoptosis inducer 455 对 MCF-7 细胞系具有细胞毒活性。Apoptosis inducer 45 通过激活 caspase-9 的裂解，进而诱导 DNA 修复蛋白 PARP 的片段化，经线粒体途径 (增加 Bax/Bcl-2 比率) 引发 MCF-7 细胞凋亡。Apoptosis inducer 45 还可以诱导 caspase-8 的裂解，随后启动 caspase-3 及其下游蛋白 PARP 的裂解，最终导致外源性细胞凋亡。Apoptosis inducer 45 可用于研究乳腺癌。

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Apoptosis inducer 45

Apoptosis inducer 45 Chemical Structure

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Apoptosis inducer 45 相关抗体

Top Publications Citing Use of Products

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Apoptosis inducer 45 is an apoptosis inducer. Apoptosis inducer 45 is cytotoxically active against the MCF-7 cell line. Apoptosis inducer 45 elicits MCF-7 cell apoptosis via the mitochondrial pathway (increases the Bax/Bcl-2 ratio) by activating cleavage of caspase-9, thereby inducing the fragmentation of DNA repair protein PARP. Apoptosis inducer 45 also can induce caspase-8 cleavage, subsequently initiating cleavage of caspase-3 and its downstream protein PARP to culminate in the extrinsic apoptosis. Apoptosis inducer 45 can be used in the research of breast cancer[1].

IC50 & Target[1]

Caspase 3

 

Caspase 9

 

Caspase 8

 

PARP

 

Bax

 

Bcl-2

 

体外研究
(In Vitro)

Apoptosis inducer 45 (Compound 11s) 抑制细胞增殖，对 A549、MCF-7、HL-7702 和 MDA-MB-231 细胞的 IC50 值分别为 3.56、4.93、7.76 和 13.35 μM[1]。
Apoptosis inducer 45 (2.5-10 μM, 24 h) 通过外源性和内源性途径诱导 MCF-7 细胞凋亡[1]。
Apoptosis inducer 45 (2.5-10 μM, 24 h-14 d) 对 MCF-7 细胞生长表现出浓度和时间依赖性的抑制作用，并抑制集落形成[1]。
Apoptosis inducer 45 (2.5-10 μM, 72 h) 显著降低 MCF-7 细胞的迁移能力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis inducer 45 相关抗体:

Apoptosis Analysis[1]

Cell Line: MCF-7 cells
Concentration: 2.5, 5 and 10 μM
Incubation Time: 24 h
Result: led to the typical apoptotic morphological characteristics of MCF-7 cells.
Increased apoptosis rates as the concentration rises.

Cell Migration Assay [1]

Cell Line: MCF-7 cells
Concentration: 2.5, 5 and 10 μM
Incubation Time: 72 h
Result: Significantly reduced the migration ability, and the migration inhibition effect persisted for 72 hours of observation.
分子量

639.91

Formula

C41H57N3O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Apoptosis inducer 45 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptosis inducer 45Apoptosis inducer45Apoptosis inducer-45ApoptosisCaspasePARPBcl-2 Familypoly ADP ribose polymeraseAlepterolic acidStructural modificationPiperazineBreast cancerHybridInhibitorinhibitorinhibit

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