2. Anti-infection Membrane Transporter/Ion Channel Apoptosis
  3. Bacterial Fungal Na+/K+ ATPase Apoptosis Antibiotic
  4. Bafilomycin C1

Bafilomycin C1  (Synonyms: 巴菲霉素C1)

目录号: HY-130173 纯度: ≥99.0%
COA 产品使用指南

摩尔计算器

Bafilomycin C1 是从链霉菌中分离得到的大环内酯类抗生素 (antibiotic)。Bafilomycin C1 是一种有效的、特异性的、可逆的 vacuolar-type H+-ATPases 抑制剂。Bafilomycin C1 抑制革兰氏阳性菌 (bacteria) 和真菌 (fungi) 的生长。Bafilomycin C1 可诱导细胞凋亡 (apoptosis)，可用于肝细胞癌 (HCC) 的研究。

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Bafilomycin C1 Chemical Structure

Bafilomycin C1 Chemical Structure

CAS No. : 88979-61-7

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规格 价格 是否有货 数量
1 mg ￥3500
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5 mg ￥9800
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Customer Review

Bafilomycin C1 相关抗体

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bafilomycin C1 is a macrolide antibiotic isolated from Streptomyces sp. Bafilomycin C1 is a potent, specific and reversible inhibitor of vacuolar-type H+-ATPases (V-ATPases). Bafilomycin C1 inhibits growth of gram-positive bacteria and fungi[2]. Bafilomycin C1 induces cell apoptosis and can be used for the study of hepatocellular carcinoma (HCC)[2].

IC50 & Target

Macrolide

 

体外研究
(In Vitro)

Bafilomycin C1 (0.33-10 μM; 6 days) inhibits the growth and proliferation of SMMC7721 and HepG2 cells in a timeand dose-dependent manner[2].
Bafilomycin C1 (0.33-3.3 μM; 24 hours) decreases cyclin D3, cyclin E1, CDK2, CDK4, and CDK6 expression in both mRNA and protein expression in SMMC7721 cells[2].
Bafilomycin C1 (3.3-10 μM; 24 hours) causes morphological alterations and increases the population of apoptotic cells by Hoechst 33258 (HY-15558) staining compared to vehicle[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bafilomycin C1 相关抗体:

Cell Viability Assay[2]

Cell Line: SMMC7721 cell and HepG2 cell
Concentration: 0.33 μM, 1.1 μM, and 3.3 μM for SMMC7721
1.1 μM, 3.3 μM, and 10.0 μM for HepG2
Incubation Time: 6 days
Result: Retarded the cell growth.

Western Blot Analysis[2]

Cell Line: SMMC7721 cells
Concentration: 3.3 μM
Incubation Time: 24 hours
Result: Decreaed cyclin D3/E1,CDK2/4/6 protein expression and increased p21.

Apoptosis Analysis[2]

Cell Line: SMMC7721 and HepG2 cells
Concentration: 3.3 μM; 10 μM
Incubation Time: 24 hours
Result: Induced apoptosis in SMMC7721 and HepG2 cells.
体内研究
(In Vivo)

Bafilomycin C1 (subcutaneous injection; 0.2 mg/kg; 20 days) retards the tumor growth without apparent adverse reactions or side effects in nude mice model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice (weighing 18-20 g) subcutaneous injected by SMMC7721 cell suspension (5×106 cells/100 μL)[2]
Dosage: 0.2 mg/kg
Administration: Subcutaneous injection; 20 days
Result: Suppressed tumor growth of SMMC7721 tumor xenografts.
分子量

720.89

Formula

C39H60O12
CAS 号
性状

固体

颜色

White to off-white

中文名称

巴菲霉素C1
结构分类
初始来源

Streptomyces sp
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 5 mg/mL (6.94 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3872 mL 6.9359 mL 13.8717 mL
5 mM 0.2774 mL 1.3872 mL 2.7743 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

以下溶解方案源自文献，仅供参考，建议您先取少量样品进行尝试。

  • 方案 一

    Bafilomycin C1 (0.2 mg/kg body weight, dissolved in 60% 1,2-propanediol)[2]

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥99.0%

COA (194 KB)

产品使用指南 (1538 KB)
参考文献

Bafilomycin C1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3872 mL 6.9359 mL 13.8717 mL 34.6794 mL
5 mM 0.2774 mL 1.3872 mL 2.7743 mL 6.9359 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bafilomycin C188979-61-7巴菲霉素C1Bafilomycin C 1Bafilomycin C-1BacterialFungalNa+/K+ ATPaseApoptosisAntibioticSodium potassium pumpprokaryoticeukaryoticSMMC7721HepatocellularcarcinomaHCChepaticchemotherapyInhibitorinhibitorinhibit

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