1. Cell Cycle/DNA Damage Apoptosis
  2. Topoisomerase Apoptosis
  3. Belotecan

Belotecan  (Synonyms: 贝洛替康; CKD-602 free base)

目录号: HY-13566
产品使用指南

Belotecan (CKD-602 free base) 是 DNA topoisomerase I 抑制剂。Belotecan 诱导细胞凋亡以及周期阻滞。Belotecan 是一种具有抗肿瘤效应的喜树碱衍生物,可用于癌症的研究。

该游离形式化合物不稳定,推荐具有相同生物学活性的稳定盐形式 Belotecan hydrochloride

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Belotecan Chemical Structure

Belotecan Chemical Structure

CAS No. : 256411-32-2

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Belotecan (CKD-602 free base) is a DNA topoisomerase I inhibitor. Belotecan induces cell apoptosis and cell-cycle arrest. Belotecan is a camptothecin analogue with anti-tumor effects, it can be used for the research of cancer[1].

IC50 & Target

IC50: 30 ng/mL (Caski cells), 150 ng/mL (HeLa cells), 150 ng/mL (SiHa cells)[1]

体外研究
(In Vitro)

Belotecan (0-600 ng/mL; 0-72 h) time- and dose-dependently inhibits viability of Caski cells, HeLa cells and SiHa cells at 48 h with IC50 values of 30, 150 and 150 ng/mL, respectively[1].
Belotecan (0-150 ng/mL; 48 h) induces cell apoptosis and cell-cycle arrest, and affects PARP, cleaved PARP, BAX, p53, Ser15, cell cycle related protein expression and cancer invasion in cervical cancer[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: Caski, HeLa and SiHa cell lines
Concentration: 0-150 ng/mL
Incubation Time: 48 h
Result: Showed strong pro-apoptotic activities to Caski, HeLa and SiHa cells.

Western Blot Analysis[1]

Cell Line: Caski, HeLa and SiHa cell lines
Concentration: 0-150 ng/mL
Incubation Time: 48 h
Result: Increased the expression of PARP, cleaved PARP, BAX, p53, Ser15, cyclin B1, phosphorylated cyclin B1 and phospho-cdc2 (Tyr15) protein, and decreased MMP2 and VEGF protein expression.

Cell Cycle Analysis[1]

Cell Line: Caski, HeLa and SiHa cell lines
Concentration: 0-150 ng/mL
Incubation Time: 48 h
Result: Induced cell-cycle arrest in the G2/M phase in cervical cancer.

Cell Invasion Assay[1]

Cell Line: Caski, HeLa and SiHa cell lines
Concentration: 0-150 ng/mL
Incubation Time: 48 h
Result: Inhibited cancer invasion in cervical cancer.
体内研究
(In Vivo)

Belotecan (25 mg/kg; i.v. for 16 days at 4-day intervals) inhibits tumor growth in CaSki-xenografts nude mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c-nude mice with CaSki cells injection[1]
Dosage: 25 mg/kg
Administration: Intravenous injection; 25 mg/kg; 16 days at 4-day intervals
Result: Significantly inhibited the tumor growth and showed no significant difference in bodyweight of xenograft mice and the controls.
Clinical Trial
分子量

433.50

Formula

C25H27N3O4

CAS 号
中文名称

贝洛替康

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Belotecan
目录号:
HY-13566
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