1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. BMS-1166 hydrochloride

BMS-1166 hydrochloride 

目录号: HY-102011A
产品使用指南

BMS-1166 hydrochloride 是一种有效的 PD-1/PD-L1 免疫检查点抑制剂。BMS-1166 hydrochloride 诱导 PD-L1 二聚化并阻断其与 PD-1 的相互作用,IC50 为 1.4 nM。BMS-1166 hydrochloride 拮抗 PD-1/PD-L1 免疫检查点对 T 细胞活化的抑制作用。

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BMS-1166 hydrochloride Chemical Structure

BMS-1166 hydrochloride Chemical Structure

CAS No. : 2113650-05-6

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5 mg ¥2300
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生物活性

BMS-1166 hydrochloride is a potent PD-1/PD-L1 immune checkpoint inhibitor. BMS-1166 hydrochloride induces dimerization of PD-L1 and blocks its interaction with PD-1, with an IC50 of 1.4 nM. BMS-1166 hydrochloride antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation[1][2].

IC50 & Target

IC50: 1.4 nM (PD-1/PD-L1 interaction)[1].

体外研究
(In Vitro)

BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM in a homogenous time-resolved fluorescence binding assay[1]. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation. BMS-1166 dose dependently abolishes the inhibition of ECs stimulation by sPD-L1[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

677.57

Formula

C36H34Cl2N2O7

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
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× = ×
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产品名称:
BMS-1166 hydrochloride
目录号:
HY-102011A
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