1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. BMS-1166 hydrochloride

BMS-1166 hydrochloride 

目录号: HY-102011A
产品使用指南

BMS-1166 hydrochloride 是 PD-1/PD-L1 相互作用的有效抑制剂,其 IC50 值为 1.4 nM。BMS-1166 可拮抗 PD-1/PD-L1 免疫检查点对 T 细胞活化的抑制作用。

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BMS-1166 hydrochloride Chemical Structure

BMS-1166 hydrochloride Chemical Structure

CAS No. : 2113650-05-6

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BMS-1166 hydrochloride 的其他形式现货产品:

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Description

BMS-1166 hydrochloride is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.

IC50 & Target

IC50: 1.4 nM (PD-1/PD-L1 interaction)[1].

In Vitro

BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM in a homogenous time-resolved fluorescence binding assay[1]. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation. BMS-1166 dose dependently abolishes the inhibition of ECs stimulation by sPD-L1[2].

Molecular Weight

677.57

Formula

C₃₆H₃₄Cl₂N₂O₇

CAS No.

2113650-05-6

SMILES

O=C(O)[C@@H]1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C(OCCO5)C5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)C[C@H](O)C1.Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
BMS-1166 hydrochloride
目录号:
HY-102011A
需求量:

BMS-1166 hydrochloride

Cat. No.: HY-102011A