2. 抗体抑制剂
  3. Biosimilar 抗体
  4. 单克隆抗体
  5. Burosumab

Burosumab  (Synonyms: 布洛舒单抗; KRN23)

目录号: HY-P9939 纯度: 99.20%
COA 技术支持

Burosumab (KRN23) 是一种人源化 FGF23 中和抗体。Burosumab 通过中和 FGF23，阻断其对肾脏磷酸盐重吸收的抑制作用，从而提升血清磷酸盐水平，改善骨矿化异常。Burosumab 可用于 X 连锁低磷血症 (XLH) 和骨软化等疾病的研究。

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CAS No. : 1610833-03-8

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规格 价格 是否有货 数量
1 mg ￥2200
In-stock
5 mg ￥5700
In-stock
10 mg ￥8238
In-stock
50 mg   询价  
100 mg   询价  

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Burosumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Burosumab (KRN23) is a humanized FGF23-neutralizing antibody. By neutralizing FGF23, Burosumab blocks its inhibitory effect on renal phosphate reabsorption, thereby increasing serum phosphate levels and improving abnormal bone mineralization. Burosumab can be used in the research of diseases such as X-linked hypophosphatemia (XLH) and osteomalacia[1][2][3].

同型

Human IgG1(E356D/M358L) kappa
反应种属

Human
IC50 & Target

FGF23
体内研究
(In Vivo)

Burosumab (4-16 mg/kg; 皮下注射; 每周 1 次; 2 个月) 在 X-连锁低磷血症小鼠模型中对牙槽骨组织具有改善作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-week-old male Hyp mice (C57BL/6J background) with X-linked hypophosphatemia caused by PHEX gene mutation[3]
Dosage: 4 and 16 mg/kg
Administration: Subcutaneous injection; once weekly; 2 months
Result: Significantly improved dentin/cementum volume, reduced pulp chamber volume to wild-type levels, particularly with 16 mg/kg.
Enhanced alveolar bone volume fraction and mineral density, restored periodontal ligament attachment and acellular cementum continuity.
Decreased osteoid and cementoid accumulation.
Clinical Trial
基因 ID

8074  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

144.08 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

布洛舒单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized FGF23-N-His can bind Burosumab. The EC50 for this effect is 241 ng/mL.
纯度 & 产品资料
参考文献

Burosumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Burosumab1610833-03-8KRN23布洛舒单抗KRN 23KRN-23OthersX-linked hypophosphatemiaXLHInhibitorinhibitorinhibit

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