2. PROTAC Vitamin D Related/Nuclear Receptor
  3. PROTACs Androgen Receptor Molecular Glues
  4. BWA-6047

BWA-6047 是一种双重的 AR/AR-V7 和 GSPT1 PROTAC 类降解剂 (AR：DC50 = 3.7 nM；AR-V7：DC50 = 3.0 nM；GSPT1：DC50 = 1.2 nM)。BWA-6047 能够促进 AR/AR-V7 的泛素化和降解，此外通过分子胶水特性，诱导 GSPT1 和 CRBN 之间形成 PPI，导致 GSPT1 降解。BWA-6047 可用于前列腺癌的研究 (粉色: AR/AR-V7 配体 (HY-176129); 蓝色: E3 CRBN 配体 (HY-W069604); 黑色: 连接子 (HY-W069604))。

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BWA-6047

BWA-6047 Chemical Structure

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BWA-6047 相关抗体

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BWA-6047 is a dual AR/AR-V7 and GSPT1 PROTAC degrader (AR: DC50 = 3.7 nM; AR-V7: DC50 = 3.0 nM; GSPT1: DC50 = 1.2 nM). BWA-6047 promotes ubiquitination and degradation of AR/AR-V7 and, through its molecular glue properties, induces the formation of a PPI between GSPT1 and CRBN, leading to GSPT1 degradation. BWA-6047 can be used in prostate cancer research (Pink: AR/AR-V7 ligand (HY-176129); Blue: E3 CRBN ligand (HY-W069604); Black: linker (HY-W069604))[1].

分子量

768.30

Formula

C42H46ClN5O7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BWA-6047 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BWA-6047BWA6047BWA 6047PROTACsAndrogen ReceptorMolecular Gluesprostate cancerPPI22Rv1 cellsVCaP cellsDU145 cellsICR miceInhibitorinhibitorinhibit

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目录号：
HY-176128
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