2. Antibody-drug Conjugate/ADC Related Immunology/Inflammation
  3. Antibody-Drug Conjugates (ADCs) Interleukin Related
  4. Camidanlumab tesirine

Camidanlumab tesirine  (Synonyms: ADCT 301)

目录号: HY-141599
产品使用指南 技术支持

Camidanlumab tesirine (ADCT 301) 是一种 ADC，包含针对 CD25 的人 IgG1 抗体 HuMax-TAC，通过二肽可裂解接头随机偶联到吡咯并苯二氮卓 (PBD) 二聚体弹头。Camidanlumab tesirine 的药物抗体比 (DAR) 为 2.3。Camidanlumab tesirine 以皮摩尔亲和力结合人 CD25。Camidanlumab tesirine 对一组表达 CD25 的人淋巴瘤细胞系具有高效和选择性的细胞毒性。

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Camidanlumab tesirine Chemical Structure

Camidanlumab tesirine Chemical Structure

CAS No. : 1853239-04-9

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规格 价格 是否有货
1 mg ￥8600
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Camidanlumab tesirine 相关抗体

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查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Camidanlumab tesirine (ADCT 301) is an ADC comprising HuMax-TAC, a human IgG1 mAb directed against human CD25, stochastically conjugated through a dipeptide cleavable linker to a pyrrolobenzodiazepine (PBD) dimer warhead. Camidanlumab tesirine has a drug–antibody ratio (DAR) of 2.3. Camidanlumab tesirine binds human CD25 with picomolar affinity. Camidanlumab tesirine has highly potent and selective cytotoxicity against a panel of CD25-expressing human lymphoma cell lines[1].

体外研究
(In Vitro)

Camidanlumab tesirine (ADCT 301; 3, 10 ng/mL; 48 小时) 导致剂量依赖性 G2-M 停滞，在 48 小时达到最大值[1]。
Camidanlumab tesirine (10 ng/mL; 24-96 小时) 诱导细胞凋亡[1]。
Camidanlumab tesirine 在 CD25 阳性细胞系中的 GI50 值范围为 0.04-2.94 ng/mL，在CD25 阴性细胞系中的 GI50 值 >1,000 ng/mL。非结合 ADC 在抗原表达和非表达细胞系中的 GI50 值为 >1,000 ng/mL[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Camidanlumab tesirine 相关抗体:

Cell Cycle Analysis[1]

Cell Line: Karpas 299 cell
Concentration: 3, 10 ng/mL
Incubation Time: 48 hours
Result: Resulted in a dose-dependent G2-M arrest reaching a maximum at 48 hours as evidenced by a decreased percentage of cells in G0-G1 and an increased percentage in G2-M compared with untreated control.

Apoptosis Analysis[1]

Cell Line: Karpas 299 cell
Concentration: 10 ng/mL
Incubation Time: 24, 48, 60, 72 and 96 hours
Result: The peak of the early apoptosis marker Annexin-V on the cell surface of Karpas 299 cells was observed between 60 and 72 hours.
体内研究
(In Vivo)

Camidanlumab tesirine (ADCT 301; 0.1-0.6 mg/kg/天; 静脉注射; 60 天) 以剂量依赖性方式延迟肿瘤生长[1]。
通过分析带有 DAR 成分 ≥1 的结合抗体，Camidanlumab tesirine 的半衰期为 7.3 天[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6- to 8-week-old female Fox Chase SCID mice subcutaneous CD25-expressing Karpas 299 cells[1]
Dosage: 0.1, 0.2, 0.4, 0.6 mg/kg
Administration: IV; daily; 60 days
Result: Delayed tumor growth in a dose-dependent fashion with the 0.6 mg/kg cohort demonstrating 10 of 10 tumor-free survivors at day 60.
同用名

ADCT 301

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Camidanlumab tesirine 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Camidanlumab tesirine1853239-04-9ADCT 301ADCT301ADCT-301Antibody-Drug Conjugates (ADCs)Interleukin RelatedAntibody-Drug ConjugatesILADCHuMax-TACIgG1CD25pyrrolobenzodiazepinePBDDARlymphoma cell lines.Inhibitorinhibitorinhibit

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