2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Carboxyamidotriazole Orotate

Carboxyamidotriazole Orotate  (Synonyms: L-651582 Orotate; CAI Orotate)

目录号: HY-16125 纯度: 98.98%
COA 产品使用指南

摩尔计算器

Carboxyamidotriazole Orotate (L-651582 Orotate)，是一种口服生物有效的信号转导抑制剂Carboxyamidotriazole (CAI) 的 orotate 盐形式。Carboxyamidotriazole Orotate 是一种非电压性钙通道 (nonvoltage-operated calcium channels) 和钙通道介导的信号通路 (calcium channel-mediated signaling pathways) 的细胞抑制剂，具有抗癌，抗炎活性和抗血管生成作用。

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Carboxyamidotriazole Orotate Chemical Structure

Carboxyamidotriazole Orotate Chemical Structure

CAS No. : 187739-60-2

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Customer Review

Other Forms of Carboxyamidotriazole Orotate:

Carboxyamidotriazole Orotate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Carboxyamidotriazole Orotate (L-651582 Orotate) is the orotate salt form of Carboxyamidotriazole (CAI), an orally bioavailable signal transduction inhibitor. Carboxyamidotriazole Orotate is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole Orotate shows anti-tumor, anti-inflammatory and antiangiogenic effects[1][2].

体外研究
(In Vitro)

Carboxyamidotriazole Orotate (0.1-10 µM; 24-96 hours) inhibits cell proliferation of LAMA84R and K562R cell lines[1].
Carboxyamidotriazole Orotate inhibits the phosphorylation of a selected target of Bcr-Abl kinase. Tyrosine phosphorylation of CrkL is reduced by 5 µM Carboxyamidotriazole Orotate treatment[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Carboxyamidotriazole Orotate 相关抗体:

Cell Viability Assay[1]

Cell Line: LAMA84R and K562R cell lines
Concentration: 0.1, 1, 5, 10 µM
Incubation Time: 24, 48, 72, 96 hours
Result: Showed a 50% growth reduction of the chronic myelogenous leukaemia (CML) lines with 5 µM CTO at 96 h time point.

Western Blot Analysis[1]

Cell Line: LAMA84R and K562R cell lines
Concentration: 0.1, 1, 5 µM
Incubation Time: 72 and 96 hours
Result: A dose-dependent inhibition of both total and phosphorylated Bcr-Abl levels.
体内研究
(In Vivo)

Carboxyamidotriazole Orotate (342, 513 mg/kg; i.p.; Q1D×5 for two rounds) displays antitumor activity on CML xenografts[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male NOD/SCID mice four-to-five week old[1]
Dosage: 342, 513 mg/kg
Administration: i.p.; Q1D×5 for two rounds
Result: Increase survival.
Clinical Trial
分子量

580.76

Formula

C22H16Cl3N7O6
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 5 mg/mL (8.61 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7219 mL 8.6094 mL 17.2188 mL
5 mM 0.3444 mL 1.7219 mL 3.4438 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.32%

COA (262 KB) HNMR (230 KB) LCMS (133 KB)

产品使用指南 (1538 KB)
参考文献

Carboxyamidotriazole Orotate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7219 mL 8.6094 mL 17.2188 mL 43.0470 mL
5 mM 0.3444 mL 1.7219 mL 3.4438 mL 8.6094 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Carboxyamidotriazole187739-60-2L-651582CAIL651582L 651582Calcium ChannelCa2+ channelsCa channelsovariancancertoxicitychronicmyelogenousleukaemiaBcr/AblInhibitorinhibitorinhibit

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