2. Membrane Transporter/Ion Channel Cell Cycle/DNA Damage MAPK/ERK Pathway
  3. Calmodulin Checkpoint Kinase (Chk) MAPKAPK2 (MK2) MAP3K
  4. CBP-501

CBP-501 是一种细胞透过性的钙调蛋白 (calmodulin) 结合肽，也是一种G2期取消药物的候选者。CBP-501 抑制了多种Ser216 位点特异性激酶的活性，包括 MAPKAP-K2、C-Tak1、CHK1和CHK2，其IC50 值分别为 0.9 μM、1.4 μM、3.4 μM 和6.5 μM。CBP-501 可用于多种癌症研究。

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CBP-501

CBP-501 Chemical Structure

CAS No. : 565434-85-7

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规格 是否有货
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100 mg   询价  
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CBP-501 的其他形式现货产品:

Customer Review

Other Forms of CBP-501:

CBP-501 相关抗体

Top Publications Citing Use of Products

查看 Calmodulin 亚型特异性产品:

查看所有亚型
CALM1 CALM2 CALM3

查看 Checkpoint Kinase (Chk) 亚型特异性产品:

查看所有亚型
Chk1 Chk2 BUBR1

查看 MAP3K 亚型特异性产品:

查看所有亚型
MAP3K7/TAK1 MAP3K8/COT/Tpl2 MAP3K6/ASK2 MAP3K5/ASK1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CBP-501, a cell-permeable calmodulin-binding peptide and a G2-abrogating drug candidate, inhibits the activity of multiple Ser216-specific kinases, such as MAPKAP-K2, C-Tak1, CHK1 and CHK2, with IC50 values of 0.9 μM, 1.4 μM 3.4 μM and 6.5 μM, respectively. CBP-501 is used for various types of cancer[1][2].

IC50 & Target[2]

MAPKAP-K2

0.9 μM (IC50)

C-Tak1

1.4 μM (IC50)

Chk1

3.4 μM (IC50)

Chk2

6.5 μM (IC50)

体外研究
(In Vitro)

CBP-501 增强了顺铂 (CDDP) 和博来霉素 (Bleomycin) 对癌细胞在体外和体内的细胞毒性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CBP-501 相关抗体:
Clinical Trial
分子量

1929.06

Formula

C86H122F5N29O17
CAS 号
性状

固体

颜色

White to off-white

Sequence

d({4-Bz-Phe}-Ser-Trp-Ser-{pentafluoro-Phe}-{Cha}-Arg-Arg-Arg-Gln-Arg-Arg)
Sequence Shortening

d({4-Bz-Phe}-SWS-{pentafluoro-Phe}-{Cha}-RRRQRR)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

CBP-501 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CBP-501565434-85-7CBP501CBP 501CalmodulinCheckpoint Kinase (Chk)MAPKAPK2 (MK2)MAP3KCaMCalcium-Modulated ProteinMitogen-activated protein kinase activated protein kinase 2MAP kinase activated protein kinase 2MAPK activated protein kinase 2MAPKAP kinase 2MAP kinase kinase kinase, MEKK, MAPKKKcell-permeablecalmodulin-bindingplatinumtumor immunogenicitycancerInhibitorinhibitorinhibit

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产品名称：
CBP-501
目录号：
HY-16129
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