CBP-501 acetate 

CBP-501 acetate, a cell-permeable calmodulin-binding peptide and a G2-abrogating drug candidate, inhibits the activity of multiple Ser²¹⁶-specific kinases, such as MAPKAP-K2, C-Tak1, CHK1 and CHK2, with IC₅₀ values of 0.9 μM, 1.4 μM 3.4 μM and 6.5 μM, respectively. CBP-501 acetate is used for various types of cancer^[1][2].

CBP-501 acetate 增强了顺铂 (CDDP) 和博来霉素 (Bleomycin) 对癌细胞在体外和体内的细胞毒性。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1929.06 (free base)

C₈₆H₁₂₂F₅N₂₉O₁₇.xC₂H₄O₂

固体

White to off-white

d({4-Bz-Phe}-Ser-Trp-Ser-{pentafluoro-Phe}-{Cha}-Arg-Arg-Arg-Gln-Arg-Arg)

d({4-Bz-Phe}-SWS-{pentafluoro-Phe}-{Cha}-RRRQRR)

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Enzler T, et al. A multicenter, randomized phase 2 study to establish combinations of CBP501, cisplatin and nivolumab for ≥3rd-line treatment of patients with advanced pancreatic adenocarcinoma. Eur J Cancer. 2024 Apr;201:113950.  [Content Brief]

  [2]. Shi-Ken Sha, et al. Cell cycle phenotype-based optimization of G2-abrogating peptides yields CBP501 with a unique mechanism of action at the G2 checkpoint. Mol Cancer Ther. 2007 Jan;6(1):147-53.  [Content Brief]