1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. CCMI

CCMI 

目录号: HY-12150 纯度: 100.00%
产品使用指南

CCMI 是一种有效、选择性的 α7 nAChR 正向别构调节剂,不是通过正性结合位点与 α7 nAChR 结合并使其激活,能有效正向调节 α7 nAChR 上激动剂诱导的电流。CCMI 在神经系统认知功能紊乱疾病中具有潜在疗效。

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CCMI Chemical Structure

CCMI Chemical Structure

CAS No. : 917837-54-8

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Size Price Stock Quantity
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥880 In-stock
5 mg ¥800 In-stock
10 mg ¥1300 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Description

CCMI is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs. CCMI has potential in CNS diseases with cognitive dysfunction[1].

IC50 & Target

α7 nAChR[1]

In Vitro

CCMI (Compound 6) is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs[1].

Molecular Weight

388.25

Formula

C₁₉H₁₅Cl₂N₃O₂

CAS No.

917837-54-8

SMILES

O=C(NC1=CC=C(Cl)C=C1)/C(C2=CC(C)=NO2)=C/NC3=CC=C(Cl)C=C3

Shipping

Room temperature in continental US; may vary elsewhere

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (257.57 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5757 mL 12.8783 mL 25.7566 mL
5 mM 0.5151 mL 2.5757 mL 5.1513 mL
10 mM 0.2576 mL 1.2878 mL 2.5757 mL
* 请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液,并请注意储备液的保存方式和期限。
In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案,配制前请先配制澄清的储备液,再依次添加助溶剂 (为保证实验结果的可靠性,体内实验的工作
液,建议您现用现配,当天使用;澄清的储备液可以根据储存条件,适当保存;以下溶剂前的百分比是指该溶剂在您配制终溶液中的体积占比):

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.36 mM); Clear solution

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.36 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。
References

Purity: 100.00%

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
CCMI
目录号:
HY-12150
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