2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK-IN-18

CDK-IN-18 (Compound EX.161) 是一种具有口服活性，脑渗透性且选择性的 CDK2、CDK4 和 CDK6 抑制剂。CDK-IN-18 可抑制细胞周期蛋白-CDK 复合物的活性，阻止视网膜母细胞瘤蛋白 (pRb) 的磷酸化，从而阻止细胞从 G1 期向 S 期的转变。CDK-IN-18 有望用于癌症的研究，如乳腺癌 (尤其是激素受体阳性、HER2 阴性的类型)、肺癌和结直肠癌。

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CDK-IN-18 Chemical Structure

CDK-IN-18 Chemical Structure

CAS No. : 2531743-46-9

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CDK-IN-18 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDK-IN-18 (Compound EX.161) is an orally active, brain-penetrant and selective inhibitor of CDK2, CDK4, and CDK6. CDK-IN-18 inhibits the activity of cyclin-CDK complexes, blocks phosphorylation of the retinoblastoma protein (pRb), arresting the cell cycle transition from G1 to S phase. CDK-IN-18 is promising for research of cancers, such as breast cancer (especially hormone receptor-positive, HER2-negative type), lung cancer, and colorectal cancer[1][2].

IC50 & Target

CDK2

 

CDK4

 

CDK6

 

分子量

470.57

Formula

C26H30N8O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDK-IN-18 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK-IN-182531743-46-9CDKCyclin dependent kinaseCDK2CDK4CDK6pRbcancersInhibitorinhibitorinhibit

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