2. Immunology/Inflammation MAPK/ERK Pathway Apoptosis
  3. AP-1 p38 MAPK NO Synthase TNF Receptor COX Interleukin Related
  4. Chloranthalactone B

Chloranthalactone B 是一种茚满烷型倍半萜类化合物，是可以从中药 Sarcandra glabra 中分离得到的天然产物。Chloranthalactone B 通过抑制 AP-1 和 p38 MAPK 通路来抑制炎症介质的产生。

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Chloranthalactone B Chemical Structure

Chloranthalactone B Chemical Structure

CAS No. : 66395-03-7

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Chloranthalactone B 相关抗体

Top Publications Citing Use of Products

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Chloranthalactone B, a lindenane-type sesquiterpenoid, is a nature product that could be isolated from Chinese medicinal herb Sarcandra glabra. Chloranthalactone B inhibits the production of inflammatory mediators by inhibiting the AP-1 and p38 MAPK pathways[1].

体外研究
(In Vitro)

Chloranthalactone B (6.25-50 µM; 30 min) 在 LPS 刺激的 RAW264.7 细胞中具有抗炎作用并抑制 NO 产生[1]。
Chloranthalactone B (25 and 50 µM; 30 min) 抑制 LPS 处理的 RAW264.7 细胞中诱导型一氧化氮合酶 (iNOS)、环氧合酶-2 (COX-2)、肿瘤坏死因子 α (TNF-α) 和白介素-1β (IL-1β) 在细胞中的表达[1]。
Chloranthalactone B (25 and 50 µM; RAW264.7 细胞) 以浓度依赖性方式抑制 LPS 诱导的 AP-1 激活[1]。
Chloranthalactone B (25 and 50 µM; RAW264.7 细胞) 抑制 RAW264.7 细胞中 ERK、JNK 和 p38 的磷酸化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Chloranthalactone B 相关抗体:

Western Blot Analysis[1]

Cell Line: RAW264.7 cells
Concentration: 25 and 50 µM
Incubation Time: 30 min
Result: Inhibited the expression of iNOS, TNF-α, COX-2, and IL-1β in a dose-dependent manner.
Inhibited the phosphorylation of ERK, JNK, and p38 in RAW264.7 cells.
分子量

244.29

Formula

C15H16O3
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Chloranthalactone B 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Chloranthalactone B66395-03-7AP-1p38 MAPKNO SynthaseTNF ReceptorCOXInterleukin RelatedActivator Protein 1Nitric oxide synthasesNOSTumor Necrosis Factor ReceptorTNFRCyclooxygenaseILnature productstemsChinese medicinalSarcandra glabra anti-inflammatoryRAW264.7 cellsInhibitorinhibitorinhibit

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