2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Immunology/Inflammation
  3. HSP MHC
  4. CliMB-325

CliMB-325 是一种 HSP90 抑制剂，可诱导 CT26 小鼠结直肠癌细胞表面 MHC-I 的表达 (EC50 = 498 nM)。CliMB-325 可增强 T 细胞活化，且毒性较低。CliMB-325 可用于结直肠癌的研究。

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CliMB-325

CliMB-325 Chemical Structure

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CliMB-325 相关抗体

Top Publications Citing Use of Products

查看 HSP 亚型特异性产品:

查看所有亚型
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

查看 MHC 亚型特异性产品:

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MHC I MHC II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CliMB-325 is an HSP90 inhibitor that can induce MHC-I (EC50 = 498 nM) expression on the surface of CT26 murine colorectal cancer cells. CliMB-325 enhances T cell activation and exhibits lower toxicity. CliMB-325 can be used for the study of colorectal cancer[1].

IC50 & Target[1]

HSP90

 

MHC I

498 nM (EC50)

体外研究
(In Vitro)

CliMB-325 可诱导 CT26 小鼠结直肠癌细胞表面 MHC-I 的表达 (EC50 = 498 nM)[1]。
CliMB-325 对 CT26 小鼠结直肠癌细胞的细胞毒性较低，CC50 为 1.3 μM[1]。
在 MC38-OVA 细胞与 B3Z T 细胞共培养 48 小时后，CliMB-325 (1 μM，48 小时) 可使 T 细胞活化 (通过 β-半乳糖苷酶活性测定) 增加 1.6 倍[1]。
CliMB-325 可增加 290 个独特的 MHC-I 肽段，是未处理组的五倍，其中 81.3% 的肽段为 CliMB-325 组特有[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CliMB-325 相关抗体:
分子量

386.20

Formula

C15H9Cl2N9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CliMB-325 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CliMB-325CliMB325CliMB 325HSPMHCHeat shock proteinsMajor Histocompatibility ComplexCancer ImmunotherapyMHC-IMajor Histocompatibility Complex Class IClick ChemistryInhibitorinhibitorinhibit

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产品名称：
CliMB-325
目录号：
HY-179211
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