2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. (D)-PPA 1

(D)-PPA 1 是一种抗水解 D 肽拮抗剂。(D)-PPA 1 是一种有效的 PD-1/PD-L1 抑制剂。(D)-PPA 1 与 PD-1 结合的亲和力为 0.51 μM，体内外均有效。

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(D)-PPA 1 Chemical Structure

(D)-PPA 1 Chemical Structure

CAS No. : 1620813-53-7

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(D)-PPA 1 的其他形式现货产品:

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(D)-PPA 1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(D)-PPA 1 is a hydrolysisresistant d-peptide antagonist. (D)-PPA 1 serves as a potent PD-1/PD-L1 inhibitor. (D)-PPA 1 binds to PD-1 with the affinity 0f 0.51 μM with in vitro and in vivo efficacy[1].

体外研究
(In Vitro)

(D)-PPA 1 (0.2 mg/mL, 1.0 mg/mL) 在 1.0 mg/mL 时阻断 PD-1/PD-L1 之间的相互作用[1]。
(d) -ppa 1 (3.125-100 μM;24 h, 48 h) 不直接杀死肿瘤细胞，对 CT26 细胞生长无影响[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(D)-PPA 1 相关抗体:

Cell Viability Assay[1]

Cell Line: CT26 cells
Concentration: 3.125, 6.25, 12.5, 25, 50, and 100 μM
Incubation Time: 24 hours, 48 hours
Result: Left tumor cells growing normally.
体内研究
(In Vivo)

(D)-PPA 1 (2 mg/kg; 皮下注射或腹腔注射; 每天 1 次, 共 7 天) 抑制小鼠体内 CT26 肿瘤的生长[1]。
(D)-PPA 1 (40 μg/mouse in 200 μL; i.v.; single dose) 具有靶向 CT26 荷瘤小鼠肿瘤组织的能力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CT26-tumor-bearing Balb/c mice[1]
Dosage: 2 mg/kg
Administration: 1) Subcutaneous injection, for around the tumor once every day for 7 days
2) Intraperitoneal injection, once every day for 7 days 3) Intraperitoneal injection, once every day for 12 days; recorded the survival on day 13
Result: Inhibited tumor growth, and prolonged the survival in mice.
分子量

1555.65

Formula

C70H98N20O21
CAS 号
Sequence

D-{Asn-Tyr-Ser-Lys-Pro-Thr-Asp-Arg-Gln-Tyr-His-Phe}
Sequence Shortening

D-{NYSKPTDRQYHF}
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(D)-PPA 1 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(D)-PPA 11620813-53-7PD-1/PD-L1PD-1/Programmed death-ligand 1Inhibitorinhibitorinhibit

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