DM-PIT-1  (Synonyms: 3,5-Dimethyl PIT-1)

DM-PIT-1 is a PIP3/PH (phosphatidylinositol-3,4,5-triphosphate/Pleckstrin) interaction inhibitor. DM-PIT-1 decreases he expression of P-Akt, P-GSK-3-β, P-p70S6K, P-S6, P-4E-BP1. DM-PIT-1 induces apoptosis and shows anticancer activity. DM-PIT-1 has the potential for the research of ovarian cancer^[1][2].

DM-PIT-1 (25, 50, 100 µM; 12 h) 降低 U87MG 细胞中 P-Akt、P-GSK-3-β、P-p70S6K、P-S6、P-4E-BP1 的表达^[2]。
DM-PIT-1 (0-200 µM) 抑制 U87MG 细胞的细胞活力，IC₅₀ 值为 33.9 µM^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DM-PIT-1 (0.4 mg/kg; i.v.; daily for 8 days) 在 4T1 乳腺癌模型中显示出抗肿瘤活性^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

345.37

3,5-Dimethyl PIT-1

C₁₆H₁₅N₃O₄S

701947-53-7

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Riehle RD, et al. Micellar formulations of pro-apoptotic DM-PIT-1 analogs and TRAIL in vitro and in vivo. Drug Deliv. 2013 Feb;20(2):78-85.  [Content Brief]

  [2]. Miao B, et al. Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20126-31.  [Content Brief]