2. GPCR/G Protein
  3. Guanylate Cyclase
  4. Dolcanatide

Dolcanatide 是一种具有口服活性的 GC-C (鸟苷酸环化酶-C) 激动剂。Dolcanatide 具有通便、抗痛和抗炎的活性，可用于炎症性肠病的研究。

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Dolcanatide Chemical Structure

Dolcanatide Chemical Structure

CAS No. : 1092457-65-2

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规格 价格 是否有货 数量
1 mg ￥2200
In-stock
5 mg ￥5500
In-stock
10 mg   询价  
50 mg   询价  

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Customer Review

Dolcanatide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dolcanatide is an orally active GC-C (guanylate cyclase-C) agonist. Dolcanatide shows laxative, anti-nociceptive and anti-inflammatory activity. Dolcanatide can be used in inflammatory bowel disease research[1][2].

体外研究
(In Vitro)

Dolcanatide (0-10 μM; 30 min) activates GC-C receptors to stimulate cGMP synthesis in a dose-dependent manner in T84 cells[2].
Dolcanatide (1 μM; 16 h) suppresses lipopolysaccharide-induced paracellular permeability in Caco-2 and T84 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dolcanatide 相关抗体:

Cell Viability Assay[2]

Cell Line: T84 cells
Concentration: 0-10 μM
Incubation Time: 30 min
Result: Showed EC50 value of 0.28 μM.
体内研究
(In Vivo)

Dolcanatide (oral administration; 0.01 and 0.05 mg/kg; once) alleviates TNBS-induced rectal allodynia in rats[1].
Dolcanatide (oral administration; 0.01 and 0.05 mg/kg; once) alleviates stress-induced colorectal hypersensitivity (CRD) in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: TNBS-induced rectal allodynia in rats[1]
Dosage: 0.01 and 0.05 mg/kg
Administration: Oral administration; 0.01 and 0.05 mg/kg; once
Result: Attenuated the TNBS-induced increase in the number of abdominal contractions (distending pressures up to 60 mmHg).
Animal Model: Stress-induced visceral hypersensitivity in Wistar rats[1]
Dosage: 0.01 and 0.05 mg/kg
Administration: Oral administration; 0.01 and 0.05 mg/kg; once
Result: Resulted in a significant reduction in the rate of PRS (partial restraint stress)-induced abdominal contractions with increasing CRD (colorectal distension) pressures.
Clinical Trial
分子量

1681.89

Formula

C65H104N18O26S4
CAS 号
性状

固体

颜色

White to off-white

Sequence

{d-Asn}--Asp-Glu-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-{d-Leu} (Disulfide bridge: Cys4-Cys12; Cys7-Cys15)
Sequence Shortening

{d-Asn}-DECELCVNVACTGC-{d-Leu} (Disulfide bridge: Cys4-Cys12; Cys7-Cys15)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Stored under nitrogen, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (59.46 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.5946 mL 2.9728 mL 5.9457 mL
5 mM 0.1189 mL 0.5946 mL 1.1891 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.39%

COA (202 KB) RP-HPLC (111 KB) MS (225 KB)

产品使用指南 (1538 KB)
参考文献

Dolcanatide 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5946 mL 2.9728 mL 5.9457 mL 14.8642 mL
5 mM 0.1189 mL 0.5946 mL 1.1891 mL 2.9728 mL
10 mM 0.0595 mL 0.2973 mL 0.5946 mL 1.4864 mL
15 mM 0.0396 mL 0.1982 mL 0.3964 mL 0.9909 mL
20 mM 0.0297 mL 0.1486 mL 0.2973 mL 0.7432 mL
25 mM 0.0238 mL 0.1189 mL 0.2378 mL 0.5946 mL
30 mM 0.0198 mL 0.0991 mL 0.1982 mL 0.4955 mL
40 mM 0.0149 mL 0.0743 mL 0.1486 mL 0.3716 mL
50 mM 0.0119 mL 0.0595 mL 0.1189 mL 0.2973 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dolcanatide1092457-65-2Guanylate Cyclaseoral activitylaxativeanti-nociceptive activityanti-inflammatory activityinflammatory bowel diseaseCaco-2T84Inhibitorinhibitorinhibit

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目录号：
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